ArticleScientific reports2025
Global trends and burden of brain and central nervous system cancers in adolescents and young adults GBD 2021 study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Identification of a lncRNA prognostic signature reveals that SNAI3-AS1 cooperates with erastin to reshape macrophage polarization in glioma.Medical oncology (Northwood, London, England) · 2026Article
- Epidemiology of brain and central nervous system cancers in children and adolescents.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Adolescents and young adults with predominantly low grade primary central nervous system tumors: patient reported socioeconomic outcomes and health-related quality of life ten years after diagnosis.Journal of neuro-oncology · 2026Article
- Translation and Validation of the Neurologic Assessment in Neuro-Oncology Scale into Indonesian (NANO-Ina).Asian Pacific journal of cancer prevention : APJCP · 2026Article
- Global burden of brain and central nervous system cancer in 185 countries, and projections up to 2050: a population-based systematic analysis of GLOBOCAN 2022.Journal of neuro-oncology · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
Brain and central nervous system (CNS) cancers are a major cause of cancer-related mortality and morbidity among adolescents and young adults (AYAs) aged 15-39, presenting significant global health challenges despite advances in treatment. This study assesses the global burden and future trends of CNS cancers in AYAs using data from the Global Burden of Disease (GBD) 2021 database. Data on incidence, mortality, and disability-adjusted life years (DALYs) from 1990 to 2021 were analyzed for 204 countries and territories. Age-standardized rates for incidence (ASIR), mortality (ASMR), and DALYs (ASDR) were calculated, with temporal trends assessed using Joinpoint regression and future projections estimated using the Bayesian Age-Period-Cohort (BAPC) model. Disparities were evaluated using the Socio-Demographic Index (SDI), a composite measure of income, education, and fertility rates. In 2021, global CNS cancer incidence among AYAs was 57,645 cases, with a prevalence of 271,770. The ASIR was 1.92 per 100,000, the ASMR 0.95 per 100,000, and DALYs totaled 1,744,650. High-SDI regions reported higher ASIR but lower ASMR and ASDR. By 2040, case numbers are projected to rise, while age-standardized rates may stabilize or decline. This study highlights significant global disparities in CNS cancer burden, calling for investments in cancer registries, equitable healthcare access, and tailored prevention and treatment strategies.
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