Evidence map›Paper›PMID 40379718›Full record

ArticleScientific reports2025

Gene expression and agent-based modeling improve precision prognosis in breast cancer.

Padmasri Sridharan, Mini Ghosh

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Development of a prognostic prediction model incorporatingJournal of gastrointestinal oncology · 2026
    Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Padmasri SridharanDepartment of Mathematics, School of Advanced Sciences, Vellore Institute of Technology, Chennai, 600127, India.
Mini GhoshDepartment of Mathematics, School of Advanced Sciences, Vellore Institute of Technology, Chennai, 600127, India. minighosh@vit.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer survival is hard to predict because of the complex ways genes and cells interact. This study offers a new method to improve these predictions by combining gene expression profiling (GEP) with agent-based modeling (ABM). First, GEP will pinpoint genes that are important in breast cancer development. Then, a mathematical model will be built to show how these genes influence cell behavior. This data will be used in ABM to simulate tumor growth and treatment response. The ABM allows us to virtually test different treatments and see how they might affect patient survival. Finally, the model's accuracy will be checked against real patient data and compared to other models. By combining the strengths of GEP and ABM, this research could significantly improve breast cancer survival prediction. ABM's ability to analyze interactions mathematically could pave the way for more personalized and effective treatments.

Indexed as

Breast NeoplasmsGene Expression ProfilingGene Expression Regulation, NeoplasticModels, BiologicalFemaleHumansModels, TheoreticalPrecision MedicinePrognosisAgent-based modelBreast cancerGene expression profilingMachine learningMathematical modelingSurvival predictions

Identifiers

PMID40379718
PMCPMC12084417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.