Sex differences in physical activity dose-response effects on site-specific bone mineral density during childhood and adolescence.

Shengrong Ouyang, Dingding Cao, Yan Yin, Feifei Ma, Gang Ren

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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5 · Who and what money

Authors and funding

5 authors.

Shengrong OuyangDepartment of Biochemistry and Immunology, Capital Institute of Pediatrics, Beijing, China.

Dingding CaoDepartment of Biochemistry and Immunology, Capital Institute of Pediatrics, Beijing, China.

Yan YinDepartment of Integrated Early Childhood Development, Capital Institute of Pediatrics, Beijing, China.

Feifei MaDepartment of Biochemistry and Immunology, Capital Institute of Pediatrics, Beijing, China. mafei0817@163.com.

Gang RenDepartment of Orthopedics, Capital Center for Children's Health, Capital Medical University , No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China. rengang1985@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physical activity (PA) serves as a modifiable determinant of bone mineral density (BMD). However, sex- and site-specific dose-response relationships remain poorly defined. Leveraging data from the National Health and Nutrition Examination Survey (NHANES 2011-2014), this cross-sectional study investigated sex-specific associations between accelerometer-derived PA (volume and intensity) and site-specific BMD in 2,659 children and adolescents aged 8-19 years. BMD assessment was conducted via dual-energy X-ray absorptiometry, and PA was quantified using monitor-independent movement summary units (MIMS). Linear and nonlinear analyses revealed distinct patterns: boys exhibited stronger linear associations between PA volume and BMD at weight-bearing sites (e.g., pelvis, arms, and legs; β = 0.003-0.004, P < 0.05), and girls demonstrated nonlinear thresholds (e.g., volume threshold: 15.0 × 10

Indexed as

Bone DensityExerciseSex CharacteristicsAbsorptiometry, PhotonAccelerometryAdolescentChildCross-Sectional StudiesFemaleHumansMaleNutrition SurveysSex FactorsYoung AdultBone mineral densityDose-responsePediatricPhysical activitySex differences.

Identifiers

PMID40379716

DOI10.1038/s41598-025-01807-4

PMCPMC12084363

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.