ArticleDental materials : official publication of the Academy of Dental Materials2025
Bond preservation in caries-affected dentin restored with acrylamide-based adhesives.
Article in Dental materials : official publication of the Academy of Dental Materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of Er: YAG laser dentin pretreatment on composite bonding: a systematic review and meta-analysis.Lasers in medical science · 2025Pooled it
- Enhancing dentin bonding with catechol-based monomers by tailoring photoinitiator systems to overcome radical inhibition.Dental materials : official publication of the Academy of Dental Materials · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
objectivesMulti-acrylamides have been shown to enhance the bond stability of the adhesive interface in sound dentin (SD). This study aimed to evaluate the performance of triacrylamides as primers for improving bonding efficacy in caries-affected dentin (CAD). MATERIALS AND
methodsCaries was induced in dentin using a 5-day microcosm biofilm model, and demineralization was characterized by ATR/FTIR spectroscopy. Primers were formulated with glycerol dimethacrylate (50 %) combined with secondary (TAAEA) or tertiary (TMAAEA) triacrylamides, HEMA (control), or dopamine methacrylamide (Dopa) with HEMA or TMAAEA, in a solvent mixture (ethanol/water, 70/30, 40 vol%). CAD and SD were treated with a three-step etch-and-rinse adhesive, restored with resin composite, and sectioned (1 mm²) for microtensile bond strength (μTBS, n = 6) testing after 24 h and six months of water storage at 37 °C. Collagen degradation (hydroxyproline assay, n = 5), in situ zymography (n = 2), and monomer viscosity (n = 3) were also evaluated. Data were analyzed using ANOVA and Tukey's post hoc test (α=0.05).
resultsIn SD, all acrylamides and the control exhibited stable or increased μTBS after six months (>50 MPa). For CAD, bond strengths were comparable to SD, except for HEMA, which consistently showed lower μTBS (<40 MPa). CAD demonstrated reduced mineral content, elevated hydroxyproline release, and greater collagen degradation (p < 0.001). Acrylamides indirectly protected collagen by mitigating enzymatic activity and exhibited higher viscosity than HEMA. SIGNIFICANCE: Multi-acrylamides effectively preserve the structural integrity of collagen and sustain bond strength in both sound and caries-affected dentin, contributing to the longevity and performance of adhesive restorations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.