ArticleHeart (British Cardiac Society)2025
Retinal image-based deep learning for mild cognitive impairment detection in coronary artery disease population.
Article in Heart (British Cardiac Society), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06102226 (Deep Learning Algorithm for Detecting Obstructive Coronary Artery Disease Using Fundus Photographs), which is not on this map. Cited by 1 paper.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Deep Learning Algorithm for Detecting Obstructive Coronary Artery Disease Using Fundus Photographs
Who cites it
1 citing paper in PubMed.
- Deep Learning-Derived Retinal Age Detects Cognitive Impairment.Ophthalmology science · 2026Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoronary artery disease (CAD) is linked to an increased risk of mild cognitive impairment (MCI). Effective and convenient screening methods for identifying MCI from the CAD population are still lacking. This study aims to develop a deep learning model using fundus images to optimise MCI diagnosis in the CAD population, achieving early intervention and improving prognosis.
methodsPatients with CAD (at least one ≥50% stenosis) from July 2021 to July 2023 at Beijing Anzhen Hospital were included in the single-centre cross-sectional study. Eligible patients from July 2021 to May 2023 were randomly assigned in an 8:2 ratio for training and internal testing of the model. Patients enrolled from June 2023 to July 2023 were included in the external validation group. Four different convolutional neural network architectures were used to train the subjects' fundus images. The reference standards were a Mini-Mental State Examination (MMSE) score of <27 and a Montreal Cognitive Assessment (MoCA) score of <26, respectively. A comprehensive visual model of MCI detection was established through model integration.
resultsA total of 9009 eligible images from 4357 patients with CAD were collected. The artificial intelligence (AI) algorithm based on the MMSE achieved an area under the curve (AUC) of 0.832 (95% CI 0.800 to 0.863) in the test group and 0.776 (95% CI 0.730 to 0.821) in the validation group. The AI algorithm based on the MoCA achieved an AUC of 0.764 (95% CI 0.742 to 0.785) in the test group and 0.725 (95% CI 0.701 to 0.750) in the validation group. The calibration curves of the internal test sets of the two models exhibited a good calibration effect. The results of decision curves revealed extensive clinical application value.
conclusionThe AI algorithm trained on fundus images in this study exerted promising performance in screening MCI in the CAD population and might be a non-invasive and effective alternative for early diagnosis of the disease. TRIAL REGISTRATION NUMBER: NCT06102226.
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