Evidence map›Paper›PMID 40379330›Full record

ArticleBMJ open2025

Application of diagnostic criteria in paediatric complex regional pain syndrome: a scoping review protocol.

See Wan Tham, Rebecca Lee, Lisa-Marie Rau, Navil Firoze Sethna, Elisabeth Mueller Nylander, Lorenzo Fabrizi, Julia Wager, Helen Koechlin

Abstract read
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

See Wan ThamDepartment of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, Washington, USA see.tham@seattlechildrens.org.ORCID http://orcid.org/0000-0003-4488-2028
Rebecca LeeCenter for Epidemiology, Center for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, The University of Manchester Faculty of Biology Medicine and Health, Manchester, UK.ORCID http://orcid.org/0000-0002-4559-1647
Lisa-Marie RauGerman Paediatric Pain Centre, Children's and Adolescents' Hospital Datteln, Datteln, Germany.ORCID http://orcid.org/0000-0002-5144-7166
Navil Firoze SethnaAnesthesiology, Critical Care and Pain Medicine, Harvard Medical School, Boston Children's Hospital, Boston, Massachusetts, USA.
Elisabeth Mueller NylanderLibrary and Information Commons, Seattle Children's Research Center, Seattle Children's Hospital, Seattle, Washington, USA.ORCID http://orcid.org/0000-0003-2621-6080
Lorenzo FabriziDepartment of Neuroscience, Physiology and Pharmacology, Division of Biosciences, University College London, London, UK.ORCID http://orcid.org/0000-0002-9582-0727
Julia WagerGerman Paediatric Pain Centre, Children's and Adolescents' Hospital Datteln, Datteln, Germany.ORCID http://orcid.org/0000-0003-4493-6356
Helen KoechlinPsychosomatics and Psychiatry, University Children's Hospital Zürich, Zürich, Switzerland.

Funding

Sleep deficiency and autonomic function in pediatric chronic abdominal painK23DK118111 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI THAM, SEE WAN · 2019 to 2023
$1.0M
NIDDK NIH HHS K23 DK118111
6 · The paper itself

Abstract

introductionThere are no validated paediatric-specific diagnostic criteria for complex regional pain syndrome (CRPS). As a result, diagnostic tools developed for adults (eg, Budapest Criteria, Japanese Diagnostic Criteria, Veldman Criteria) are frequently applied in the paediatric population. However, the clinical presentations and trajectories of children can differ from adults. Given that treatment outcomes are linked to early diagnosis and intervention, the lack of paediatric-specific screening or diagnostic tools is an important knowledge gap. We aim to identify the frequency of individual criteria used in diagnosing CRPS in children and adolescents in existing literature, summarise assessment methods used to establish the diagnosis, and provide recommendations for research and clinical application.

methodsThe following databases and platforms will be searched for articles published from 2003 (year the Budapest Criteria was developed) onward: CINAHL, CENTRAL, Embase, Ovid MEDLINE, PubMed, PsycINFO and Web of Science. Our search strategy will use subject headings and text words related to the concepts of CRPS in paediatric populations, with study inclusion criteria from birth up to 18 years old, and a diagnosis of CRPS. Data will be extracted by our multidisciplinary team and findings will be reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews. ETHICS AND DISSEMINATION: This study does not involve human participants or unpublished data; therefore, approval from a human research ethics committee is not required. The findings of this scoping review will be disseminated through academic conferences and peer-reviewed publications.

Indexed as

Complex Regional Pain SyndromesAdolescentChildHumansResearch DesignScoping Reviews as TopicAdolescentChildChronic Pain

Identifiers

PMID40379330
PMCPMC12086909

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.