Evidence map›Paper›PMID 40379317›Full record

ArticleBMJ open2025

Opioid-free anaesthesia and postoperative quality of recovery in patients undergoing supratentorial tumour resection: protocol for a randomised controlled trial.

Yuxuan Fu, Yang Zhou, Yidan Cui, Youxuan Wu, Tianyuan Wang, Yang Li, Yun Yu, Ruquan Han

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06607029 (Opioid-free Anesthesia Protocol on the Quality of Recovery After Neurosurgical Supratentorial Tumor Resection), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06607029 narecruitingnot on this map

Opioid-free Anesthesia Protocol on the Quality of Recovery After Neurosurgical Supratentorial Tumor Resection: A Randomized, Controlled, Clinical Trial

TypeinterventionalSponsorBeijing Tiantan HospitalRan2024 to 2026Enrolled170ConditionsSupratentorial TumorsArmsthe opioid-based control group, the opioid-free anesthesia group
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuxuan FuDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID http://orcid.org/0009-0004-1718-2362
Yang ZhouDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yidan CuiBeijing Nuclear Industry Hospital, Beijing, China.
Youxuan WuDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Tianyuan WangDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yang LiDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yun YuDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID http://orcid.org/0000-0001-6580-9554
Ruquan HanDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China ruquan.han@gmail.com.ORCID http://orcid.org/0000-0003-4335-8670

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOpioids play a pivotal role in being capable of effectively blocking the pain and stress responses triggered by procedures such as surgery and intubation. However, it should not be overlooked that opioids have numerous side effects, such as respiratory depression, postoperative nausea and vomiting. These effects can raise intracranial pressure, posing a life-threatening risk in neurosurgical patients. Opioid-free anaesthesia can prevent or significantly reduce opioid usage. The aim of this study is to investigate the effect of opioid-free anaesthesia on the quality of recovery in patients undergoing supratentorial tumour resection in neurosurgery. METHODS AND ANALYSIS: This is a single-centre, randomised controlled clinical trial. A total of 170 patients receiving general anaesthesia will be randomised in a 1:1 ratio into two groups, one receiving opioid-free anaesthesia and the other receiving opioid-based anaesthesia. The primary outcome measure is the Quality of Recovery-15 Score on the second day after surgery. The secondary outcomes include the Quality of Recovery Score on the fifth day, the incidence of nausea and vomiting within 48 hours, the NRS Pain Score on the second and fifth days, the sleep quality on the second and fifth days after surgery, and the incidence of chronic pain at 3 months and 6 months after surgery. ETHICS AND DISSEMINATION: This study received official approval from the Ethics Committee of Beijing Tiantan Hospital, Capital Medical University, on 9 September 2024 (KY2024-219-02). The findings of this study are intended to be disseminated through publications in international peer-reviewed journals, presentations at national and international academic conferences, and broad distribution via online platforms. TRIAL REGISTRATION NUMBER: ClincalTrials.gov, NCT06607029 (15 September 2024).

Indexed as

Analgesics, OpioidAnesthesia, GeneralAnesthesia Recovery PeriodNeurosurgical ProceduresPostoperative PainSupratentorial NeoplasmsAdultFemaleHumansMaleMiddle AgedPostoperative Nausea and VomitingRandomized Controlled Trials as TopicAnalgesics, OpioidAnaesthesia in neurologyClinical ProtocolsNeurosurgeryPain management

Identifiers

PMID40379317
PMCPMC12083393

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.