ArticleNeuron2025
Network influence determines the impact of cortical ensembles on stimulus detection.
Article in Neuron, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Acetylcholine enhances deviance detection in Hodgkin-Huxley neuronal networks.Cognitive neurodynamics · 2026Article
- Tuft Dendrite Spikes Are Accompanied by Selective Input From Distinct Functional Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Probing inter-areal computations with a two-photon holographic mesoscope.Nature neuroscience · 2026Article
- The curriculum effect in visual learning: The role of readout dimensionality.PLoS computational biology · 2026Article
- The Importance of Synchrony in the Neural Control of Movement.bioRxiv : the preprint server for biology · 2026Article
- Article
- Tuft dendrite spikes are accompanied by selective input from distinct functional networks.bioRxiv : the preprint server for biology · 2026Article
- Spatiotemporal Divergence Between Intrinsic And Evoked Cortical Activity Predicts Visual Detection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Enhancing Experience-Dependent Plasticity Accelerates Vision Loss in a Murine Model of Retinitis Pigmentosa.Investigative ophthalmology & visual science · 2026Article
- Technical development of two-photon optogenetic stimulation and its potential application to brain-machine interfaces.Neurophotonics · 2026Review
- Routing of task-relevant information in mouse PPC during continuous visuomotor control.bioRxiv : the preprint server for biology · 2025Article
- Enhancing experience-dependent plasticity accelerates vision loss in a murine model of retinitis pigmentosa.bioRxiv : the preprint server for biology · 2025Article
- A scalable, all-optical method for mapping synaptic connectivity with cell-type specificity.bioRxiv : the preprint server for biology · 2025Article
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2 authors.
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Abstract
Causally connecting neural activity patterns to behavioral decisions is essential to understand the neural code but requires direct perturbation of the pattern of interest with high specificity. We combined two-photon imaging and cellular-resolution holographic optogenetic photostimulation to causally test how neural activity in the mouse visual cortex is read out to detect visual stimuli. Contrary to expectations, targeted activation of visually sensitive neural ensembles did not preferentially modify behavior compared with targeting randomly selected ensembles. Instead, an activated ensemble's effect on local network activity was the main predictor of its impact on perception. This suggests that downstream regions summate visual cortex activity without preferentially weighting more informative neurons, a notion confirmed by analyzing the impact of photostimulation on decoding models of neural activity. This work challenges conventional notions for how sensory representations mediate perception and demonstrates that perturbing activity is essential to determine which features of neural activity drive behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.