Evidence map›Paper›PMID 40378612›Full record

ArticleAddictive behaviors2025

Biomarkers of secondhand smoke and vaping exposure among U.S. Adolescents.

Hongying Daisy Dai, Amber K Brown Keebler, Brian Young

Abstract read
In one paragraph

Article in Addictive behaviors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hongying Daisy DaiCollege of Public Health University of Nebraska Medical Center, Omaha, NE, United States. Electronic address: daisy.dai@unmc.edu.
Amber K Brown KeeblerCollege of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, United States.
Brian YoungCollege of Public Health University of Nebraska Medical Center, Omaha, NE, United States; College of Osteopathic Medicine, Kansas City University, Kansas City, MO, United States.

Funding

Health Effects of E-cigarette Use on Brain Functions and Cognitive Development among Adolescents: A US Population-Based StudyR01DA060466 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI NEAL L BENOWITZ, Hongying Daisy Dai · 2024 to 2026
$1.1M
NIDA NIH HHS R01 DA060466
6 · The paper itself

Abstract

backgroundDespite reductions in smoking use among adults and adolescents, e-cigarette use has increased, raising a new public health concern.

methodsWe analyzed Wave 4 (2016-2018) data from the Population Assessment of Tobacco and Health (PATH) Study to assess biomarkers of exposure to secondhand smoke and vaping aerosols among U.S. adolescents (age range 12-17). Participants with no current tobacco use in the past 30 days were divided into four mutually exclusive groups: no exposure, exposure to secondhand smoke (SHS) only, exposure to secondhand aerosol (SHA) only, and dual exposure to both (SHD).

resultsAmong 2,379 adolescents (mean[SD] of age = 14.4[0.02]), 1.5 % reported SHA, 18.3 % reported SHS, and 2.8 % reported SHD. Mean concentrations of cotinine were significantly higher among those exposed to SHA only (0.5 ng/mg creatinine, p = 0.04), SHS (3.0,p < 0.0001), or SHD (2.5,p < 0.0001) than among those with no exposure (0.2). As compared to the no-exposure group, both SHS and SHD groups also had higher mean concentrations of carcinogen, NNAL (4.1 and 2.8 pg/mg creatinine, respectively, vs. 0.9, p < 0.0001) and exposure to SHS had a higher level of CYMA (1.8 vs. 1.1 ng/mg creatinine, p < 0.0001). In comparison with the SHA group, the SHS and SHD groups had 6.8 and 3.6 times higher levels of cotinine and 4.6 and 2.2 times higher levels of NNAL, respectively; the SHS group also had higher levels of AAMA and CYMA.

conclusionsSecondhand vaping aerosol poses a lower exposure risk to youth non-tobacco users than combustible cigarette smoke. The distinct exposure patterns emphasize the importance of implementing tobacco-free policies to reduce youth exposure to environments where combustible tobacco or e-cigarette use occurs.

Indexed as

Tobacco Smoke PollutionVapingAdolescentAerosolsBiomarkersChildCotinineElectronic Nicotine Delivery SystemsFemaleHumansMaleUnited StatesAerosolsBiomarkersCotinineTobacco Smoke Pollution

Identifiers

PMID40378612
PMCPMC13485149

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.