Evidence map›Paper›PMID 40378440›Full record

ArticleJournal of inorganic biochemistry2025

Selective isotope labeling probes the chemical capacity and reaction mechanism of a heterobimetallic Mn/Fe protein.

Yunqiao J Gan, Joseph M Hazel, Brian C Searle, Hannah S Shafaat

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inorganic biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yunqiao J GanDepartment of Chemistry and Biochemistry, The Ohio State University, 100 W 18th Avenue, Columbus, OH 43210, USA; Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, CA 90095, USA.
Joseph M HazelDepartment of Chemistry and Biochemistry, The Ohio State University, 100 W 18th Avenue, Columbus, OH 43210, USA.
Brian C SearlePelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA; Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA.
Hannah S ShafaatDepartment of Chemistry and Biochemistry, The Ohio State University, 100 W 18th Avenue, Columbus, OH 43210, USA; Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, CA 90095, USA. Electronic address: shafaat@ucla.edu.

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
Metallobiochemistry of Mn/Fe protein cofactorsR35GM128852 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Hannah S Shafaat · 2018 to 2026
$2.3M
NCI NIH HHS P30 CA016058NIGMS NIH HHS R35 GM128852
6 · The paper itself

Abstract

The R2-like ligand binding oxidase (R2lox) forms a novel tyrosine-valine crosslink upon O

Indexed as

IronManganeseOxidoreductasesElectron Spin Resonance SpectroscopyIsotope LabelingKineticsOxidation-ReductionRibonucleotide ReductasesIronManganeseOxidoreductasesRibonucleotide ReductasesC-H bond cleavageEPRFerritin-like superfamilyKineticsOxygen activationSpectroscopy

Identifiers

PMID40378440
PMCPMC12226152

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.