Evidence map›Paper›PMID 40378375›Full record

ArticleNeurology2025

Status Epilepticus Protocol Variation Across Accredited National Association of Epilepsy Centers Members.

Laura K Lamberta, Melissa Asmar, Megan M Fredwall, Stephanie M Ahrens, Shasha Bai, Mariah Eisner, Fred Alexander Lado, Stephan U Schuele, Dave F Clarke, Ahmed T Abdelmoity and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Laura K LambertaDivision of Neurology, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, OH.
Melissa AsmarDepartment of Neurology, University of California Davis, Sacramento, CA.
Megan M FredwallDivision of Neurology, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, OH.ORCID 0000-0003-0824-2429
Stephanie M AhrensDivision of Neurology, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, OH.
Shasha BaiPediatrics Biostatistics Core, Emory University School of Medicine, Atlanta, GA.ORCID 0000-0003-4999-327X
Mariah EisnerBiostatics Resource, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, OH.ORCID 0000-0002-4703-4342
Fred Alexander LadoDepartment of Neurology, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY.
Stephan U SchueleDepartment of Neurology, Feinberg School of Medicine Northwestern Memorial Hospital, Chicago, IL.
Dave F ClarkeDepartment of Neurology, Dell Medical School, University of Texas at Austin, TX.
Ahmed T AbdelmoityDivision of Neurology, Department of Pediatrics, Children's Mercy Hospital, Kansas City, MO.
Kathryn A DavisDepartment of Neurology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA.
Jennifer L HoppNeurology, University of Maryland Medical Center, Baltimore, MD.
Mohamad Z KoubeissiDepartment of Neurology, George Washington University, Washington, DC.
Meriem K Bensalem OwenDepartment of Neurology, University of Kentucky College of Medicine, Lexington, KY; and.
Susan T HermanBarrow Neurological Institute, Phoenix, AZ.
Adam P OstendorfDivision of Neurology, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, OH.
NAEC Center Director Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesStatus epilepticus (SE) is a neurologic emergency that requires urgent recognition and medical management. SE management remains heterogeneous across centers.

methodsWe analyzed SE treatment protocols from level 3 and level 4 epilepsy centers. Discrete data including stabilization measures, timing of treatment phases, medications, doses, and routes of administration were collected from each protocol and described using frequency for categorical variables and median for continuous variables. The distribution of treatment times and dosing were compared with the AES guideline.

resultsA total of 256 SE treatment protocols were included. Only 66% of SE protocols detailed treatment times. Doses below recommendations occurred in 4% of protocols for initial benzodiazepine (BZD) and 14% for first non-BZD medications. Infusion therapy was outlined in 61% of protocols. DISCUSSION: Despite the importance of timeliness in SE management, one third of institutional protocols did not specify treatment times. This analysis of US hospital inpatient SE protocols provides expert opinion regarding infusion therapy management and highlights gaps and targets for improvement in SE treatment.

Indexed as

AnticonvulsantsClinical ProtocolsStatus EpilepticusBenzodiazepinesHumansPractice Guidelines as TopicUnited StatesAnticonvulsantsBenzodiazepines

Identifiers

PMID40378375
PMCPMC12089659

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.