Evidence map›Paper›PMID 40378239›Full record

ArticleScience immunology2025

C/EBPα activates

Jing Chen, Tian-Tian Liu, Feiya Ou, Ray A Ohara, Suin Jo, Joshua Luke Postoak, Takeshi Egawa, Ryan B Day, Theresa L Murphy, Kenneth M Murphy and 1 more

Abstract read
In one paragraph

Article in Science immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jing ChenDepartment of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-5998-6930
Tian-Tian LiuDepartment of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Feiya OuDepartment of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-8289-4025
Ray A OharaDepartment of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-7897-3169
Suin JoDepartment of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-7575-9017
Joshua Luke PostoakDepartment of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Takeshi EgawaDepartment of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-7489-1051
Ryan B DaySection of Stem Cell Biology, Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-4376-4663
Theresa L MurphyDepartment of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-6539-8142
Kenneth M MurphyDepartment of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-3505-9630
Sunkyung KimDepartment of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-1375-6339

Funding

Molecular Pathogenesis of Acute Myeloid LeukemiaR35CA197561 · NCI · WASHINGTON UNIVERSITY · PI Timothy J. Ley · 2015 to 2026
$11.0M
The transcription factor c-MYC in lymphocyte expansion and restriction of stemnessR01AI130152 · NIAID · WASHINGTON UNIVERSITY · PI Takeshi Egawa · 2017 to 2026
$4.6M
Molecular Basis of cDC1 DevelopmentR01AI162643 · NIAID · WASHINGTON UNIVERSITY · PI MURPHY, KENNETH M · 2022 to 2025
$2.8M
Function of Wdfy4 in cross-presentation and immunityR01AI150297 · NIAID · WASHINGTON UNIVERSITY · PI MURPHY, KENNETH M · 2019 to 2023
$2.5M
Understanding the Mechanisms of DC Licensing in CD8 T Cell PrimingR01CA248919 · NCI · WASHINGTON UNIVERSITY · PI MURPHY, KENNETH M · 2021 to 2025
$2.3M
Molecular mechanisms of CD8 T cell fate decision instructed by cytokine signalingR01AI176664 · NIAID · WASHINGTON UNIVERSITY · PI Takeshi Egawa · 2024 to 2026
$1.8M
Role of HDAC7 in T-cell DevelopmentR56AI076664 · NIAID · J. DAVID GLADSTONE INSTITUTES · PI VERDIN, ERIC M. · 2010 to 2010
$483k
Mechanism of c-MYC repression by IRF8 in myeloid lineagesR21AI164142 · NIAID · WASHINGTON UNIVERSITY · PI MURPHY, KENNETH M · 2021 to 2022
$433k
Transcriptional basis of embryonic macrophage developmentR21AI163421 · NIAID · WASHINGTON UNIVERSITY · PI MURPHY, KENNETH M · 2022 to 2023
$430k
The role of EMT transcription factor Zeb2 in fetal hematopoiesisF30HL167565 · NHLBI · WASHINGTON UNIVERSITY · PI CHEN, JING · 2023 to 2025
$142k
NCI NIH HHS R01 CA248919NCI NIH HHS R35 CA197561NHLBI NIH HHS F30 HL167565NIAID NIH HHS R01 AI130152NIAID NIH HHS R01 AI150297NIAID NIH HHS R01 AI162643NIAID NIH HHS R01 AI176664NIAID NIH HHS R21 AI163421NIAID NIH HHS R21 AI164142NIAID NIH HHS R56 AI076664
6 · The paper itself

Abstract

Development of type 1 conventional dendritic cells (cDC1s) underlies the capacity to generate antiviral and antitumor immune responses. Here, we identify the basis for cDC1 development from its earliest progenitors, determining the hierarchy of several required transcription factors and uncovering a series of mandatory cis interactions between constituent enhancers within the

Indexed as

CCAAT-Enhancer-Binding ProteinsDendritic CellsEnhancer Elements, GeneticInterferon Regulatory FactorsMyeloid Progenitor CellsAnimalsInterferon Regulatory Factor-8MiceMice, Inbred C57BLCCAAT-Enhancer-Binding ProteinsInterferon Regulatory Factor-8Interferon Regulatory Factors

Identifiers

PMID40378239
PMCPMC13132473

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.