Evidence map›Paper›PMID 40378226›Full record

ArticleScience advances2025

Acoustofluidic spin control for 3D particle manipulation in droplets.

Chuyi Chen, Yuyang Gu, Joseph Rufo, Jinxin Zhang, Kaichun Yang, Ying Chen, Luke P Lee, Tony Jun Huang

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Passive Metasurface Tweezers for Multi-Scale Orbital Transport and Trapping on Elastic Plates.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chuyi ChenThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA.ORCID 0000-0001-5733-4261
Yuyang GuThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA.ORCID 0000-0002-6545-2521
Joseph RufoThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA.ORCID 0000-0001-7408-2393
Jinxin ZhangThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA.ORCID 0000-0001-6492-8519
Kaichun YangThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA.
Ying ChenThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA.ORCID 0009-0000-4812-7658
Luke P LeeDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-1436-4054
Tony Jun HuangThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA.ORCID 0000-0003-1205-3313

Funding

Development of a digital acoustofluidic system for automating liquid handling in biomedical researchR01GM141055 · NIGMS · DUKE UNIVERSITY · PI HUANG, TONY JUN · 2021 to 2024
$1.9M
Enabling Efficient, Fast, Biocompatible Exosome Separation via AcoustofluidicsR01GM132603 · NIGMS · DUKE UNIVERSITY · PI HUANG, TONY JUN · 2019 to 2022
$1.7M
NIGMS NIH HHS R01 GM132603NIGMS NIH HHS R01 GM141055
6 · The paper itself

Abstract

The rotation of objects and corresponding dynamic systems plays a critical role in applications ranging from microscale droplet-based biochemical assays to nanoscale fluid transport and targeted drug delivery. However, directly observing and controlling these rotational phenomena across these different scales remains a challenge. Here, we introduce an acoustofluidic spinning control method that dynamically guides particles into three-dimensional, periodic spatial patterns within a droplet. Using surface acoustic waves, we induce internal streaming that generates centrifugal forces counteracted by surface tension, leading to the formation of rotating Stokes waves along the droplet's equator. We show that fluid motion inside the droplet couples with these rotating waves, giving rise to a controllable superimposed helical particle orbit. These findings provide a platform for controlled rotational flows with potential applications in droplet-based microfluidics, biochemical processing, and tunable particle transport in lab-on-a-chip systems.

Indexed as

AcousticsLab-On-A-Chip DevicesMicrofluidic Analytical TechniquesMicrofluidicsParticle Size

Identifiers

PMID40378226
PMCPMC12083541

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.