Evidence map›Paper›PMID 40378225›Full record

ArticleScience advances2025

The microRNA OsmiR393 regulates rice brown planthopper resistance by modulating the auxin-ROS signaling cross-talk.

Lin Zhu, Haichao Li, Zhihuan Tao, Feilong Ma, Shujun Wu, Xuexia Miao, Liming Cao, Zhenying Shi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. RNA regulation in plants.Science China. Life sciences · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lin ZhuKey Laboratory of Germplasm Innovation and Genetic Improvement of Grain and Oil Crops (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Crop Breeding and Cultivation Research Institute, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China.ORCID 0009-0007-3690-1942
Haichao LiKey Laboratory of Plant Design, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.ORCID 0000-0002-1359-4640
Zhihuan TaoKey Laboratory of Plant Design, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.
Feilong MaKey Laboratory of Plant Genetics and Molecular Breeding, Zhoukou Normal University, Zhoukou 466001, China.
Shujun WuKey Laboratory of Germplasm Innovation and Genetic Improvement of Grain and Oil Crops (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Crop Breeding and Cultivation Research Institute, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China.
Xuexia MiaoKey Laboratory of Plant Design, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.ORCID 0000-0003-3244-0126
Liming CaoKey Laboratory of Germplasm Innovation and Genetic Improvement of Grain and Oil Crops (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Crop Breeding and Cultivation Research Institute, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China.ORCID 0000-0001-5315-9224
Zhenying ShiKey Laboratory of Germplasm Innovation and Genetic Improvement of Grain and Oil Crops (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Crop Breeding and Cultivation Research Institute, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China.ORCID 0000-0002-8441-2162

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Auxin plays critical roles in plant development and stress response. However, the roles of auxin and the immune signaling factor, reactive oxygen species (ROS), in resistance to the brown planthopper (BPH), a notorious rice-specific piercing-sucking insect that causes severe yield losses, remain unclear. We revealed that moderate naphthalene acetic acid treatment activates rice resistance to BPH, BPH infestation induces ROS accumulation, and increase in ROS content promotes BPH resistance. Underlying these phenomena, the auxin receptors OsTIR1 and OsAFB2 positively, whereas the posttranscriptional regulator OsmiR393 negatively, regulate BPH resistance. Downstream of the OsmiR393/OsTIR1 module, through successive genetic function analysis of each gene, solid genetic relationship analysis, and various biochemical assays, we established an OsmiR393/OsTIR1-OsIAA10-OsARF12-OsRbohB genetic pathway that mediates BPH resistance, in which ROS are integral. Such cross-talk between auxin and ROS reveals the intricate signaling network underlying BPH resistance, which might assist with BPH resistance breeding.

Indexed as

Disease ResistanceHemipteraIndoleacetic AcidsMicroRNAsOryzaPlant DiseasesReactive Oxygen SpeciesSignal TransductionAnimalsGene Expression Regulation, PlantPlant ProteinsIndoleacetic AcidsMicroRNAsPlant ProteinsReactive Oxygen Species

Identifiers

PMID40378225
PMCPMC12083543

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.