ArticleScience advances2025
Sheep serve as amplifying hosts of Japanese encephalitis virus, increasing the risk of human infection.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Article
- Article
- Qualitative risk assessment of Japanese encephalitis virus introduction and transmission in Pacific Island countries and territories.PLoS neglected tropical diseases · 2026Article
- Development of JEV NS1 Specific Capture-ELISA Based on a Single Monoclonal Antibody.Animals : an open access journal from MDPI · 2026Article
- Japanese encephalitis: Current status, recent progress, and persistent challenges.PLoS neglected tropical diseases · 2026Review
- Host-specific ubiquitination of prM orchestrates ESCRT recruitment to mediate efficient Japanese Encephalitis Virus assembly in vertebrates.PLoS pathogens · 2026Article
- Neuroinflammation and blood-brain barrier disruption in Japanese encephalitis virus infection: mechanisms, therapeutic targets, and intervention strategies.Archives of pharmacal research · 2026Review
- Evidence of Japanese Encephalitis Virus Exposure in Feral Pig Populations in North Queensland, Australia.Transboundary and emerging diseases · 2026Article
- The hidden threats posed by Japanese encephalitis virus genotype V.Journal of virology · 2025Review
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Authors and funding
13 authors.
Funding
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Abstract
The transmission cycle of Japanese encephalitis virus (JEV), involving pigs and birds as amplifying hosts and mosquitoes as vectors, was elucidated in the 1950s. However, factors contributing to this cycle remain unclear. Here, sheep were infected with a JEV strain isolated from sheep exhibiting neurological symptoms. The results revealed that sheep are susceptible to JEV infection and develop viremia, with levels and duration comparable to those observed in pigs, a known JEV-amplifying host. Mosquitoes fed viremic sheep blood showed an infection rate of 40.6 to 57.1%. These findings indicate that sheep can serve as amplifying hosts for JEV, potentially contributing to JEV transmission and increasing the public health risk of human infections. We propose an alternative, sheep-associated rural domestic JEV transmission cycle, which may be prevalent in specific regions where sheep are bred but pigs are not. This cycle exists along with the well-known pig-associated rural domestic and bird-associated wild cycles.
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