Evidence map›Paper›PMID 40378213›Full record

ArticleScience advances2025

Nucleosomes represent a crucial target for the intra-S phase checkpoint in response to replication stress.

Xiaoqin Liu, Bo Zhang, Yu Hua, Chuanqi Li, Xizhou Li, Daochun Kong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaoqin LiuPeking-Tsinghua Center for Life Sciences, The National Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing 100871, China.ORCID 0000-0002-0614-8212
Bo ZhangPeking-Tsinghua Center for Life Sciences, The National Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing 100871, China.ORCID 0000-0002-3918-8202
Yu HuaPeking-Tsinghua Center for Life Sciences, The National Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing 100871, China.ORCID 0009-0008-3577-8601
Chuanqi LiSuzhou Institute for Advanced Research, University of Science and Technology of China, Suzhou 215123, China.
Xizhou LiDepartment of Breast and Thyroid Surgery, Changhai Hospital, The Naval Military Medical University, Shanghai, China.ORCID 0000-0003-2471-7279
Daochun KongPeking-Tsinghua Center for Life Sciences, The National Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing 100871, China.ORCID 0000-0003-2826-385X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intra-S phase checkpoint is essential for stability of stalled DNA replication forks. However, the mechanisms underlying checkpoint regulation remain poorly understood. This study identifies a critical checkpoint target-the ubiquitin E3 ligase Brl2, revealing a new dimension of checkpoint regulation. Upon replication fork stalling, Brl2 undergoes phosphorylation at five serine residues by Cds1

Indexed as

DNA ReplicationNucleosomesS Phase Cell Cycle CheckpointsStress, PhysiologicalChromatinHistonesHumansPhosphorylationUbiquitin-Protein LigasesChromatinHistonesNucleosomesUbiquitin-Protein Ligases

Identifiers

PMID40378213
PMCPMC12083529

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.