Evidence map›Paper›PMID 40378139›Full record

Observational studyPloS one2025

Incidence and factors associated with post-intensive care syndrome among caregivers of intensive care unit survivors: Protocol for a cohort study.

Cristobal Padilla-Fortunatti, Noelia Rojas-Silva, Sergio Cortes-Maripangue, Yasna Palmeiro-Silva, Verónica Rojas-Jara, Valentina Nilo-Gonzalez, Belén Cifuentes-Avendaño, Daniel Morales-Morales, Nicolas Garces-Brito

Registry-linked trialAbstract readObservational Study
In one paragraph

Observational study in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05827354 (Incidence and Factors Associated to The Development of Post-Intensive Care Syndrome Among Family Members of Intensive Care Unit Survivors), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05827354 unknown statusnot on this map

Incidence and Factors Associated to The Development of Post-Intensive Care Syndrome Among Family Members of Intensive Care Unit Survivors: A Longitudinal Exploratory Study

TypeobservationalSponsorPontificia Universidad Catolica de ChileRan2023 to 2025Enrolled175ConditionsPost Intensive Care Syndrome, Family Members, Caregiver Burden, Critical Illness
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cristobal Padilla-FortunattiSchool Nursing, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0001-5452-8415
Noelia Rojas-SilvaSchool Nursing, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0003-1867-7557
Sergio Cortes-MaripangueAdult Intensive Care Unit, Hospital Clínico Dra. Eloísa Diaz, Santiago, Chile.
Yasna Palmeiro-SilvaInstitute for Global Health, University College London, London, United Kingdom.ORCID https://orcid.org/0000-0001-6664-1079
Verónica Rojas-JaraHospital Clínico de la Universidad de Chile, Santiago, Chile.
Valentina Nilo-GonzalezSchool Nursing, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0001-6755-7362
Belén Cifuentes-AvendañoSchool Nursing, Pontificia Universidad Católica de Chile, Santiago, Chile.
Daniel Morales-MoralesAdult Intensive Care Unit, Hospital Clínico Dra. Eloísa Diaz, Santiago, Chile.ORCID https://orcid.org/0009-0003-6823-8808
Nicolas Garces-BritoSchool Nursing, Pontificia Universidad Católica de Chile, Santiago, Chile.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDuring the last decades, intensive care unit (ICU) mortality rates have significantly decreased but this progress has come with unintended consequences for patients and their caregivers. The adverse health-related effects observed in caregivers during the post-ICU period are referred to as Post-Intensive Care Syndrome-Family (PICS-F). Despite growing awareness of PICS-F, the long-term challenges faced by caregivers of ICU patients are not well characterized with several gaps in knowledge remaining unaddressed. The proposed study aims to determine the incidence of PICS-F impairments and identify associated factors among caregivers of ICU survivors.

methodsWe plan to conduct a longitudinal prospective cohort study involving 175 caregivers of ICU patients admitted to a public hospital in Chile. Data will be collected during ICU admission, after ICU discharge, 3 months and 6 months after hospital discharge. Questionnaires will evaluate caregivers' psychological, physical and cognitive outcomes and perceived social support, resilience, family satisfaction and caregiver burden. Factors associated with PICS-F impairments will be explored using generalised linear mixed models. DISCUSSION: The current understanding of PICS-F is limited, particularly regarding the risk and protective factors associated with the syndrome among caregivers of ICU survivors. This study will contribute to addressing this gap by providing novel data about PICS-F and exploring previously unexamined factors linked to PICS-F such as family satisfaction, psychological buffers and caregiver burden.

trial registrationClinicaltrials.gov: NCT05827354. Registered on 25 April 2023.

Indexed as

CaregiversCritical CareIntensive Care UnitsSurvivorsAdultChileCohort StudiesCritical IllnessFemaleHumansIncidenceLongitudinal StudiesMaleMiddle AgedProspective StudiesSocial Support

Identifiers

PMID40378139
PMCPMC12083806

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.