ArticlePloS one2025
Protocol: Weight-adjusted effective volume of 0.5% ropivacaine for combined costoclavicular brachial plexus block-cervical plexus blocks undergoing arthroscopic shoulder surgery: A dose-finding study protocol.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRotator cuff injuries are common clinically, and arthroscopic repair is widely applied. Postoperative analgesia can be assisted by the interscalene brachial plexus block; however, it comes with side effects, among which a high incidence of hemidiaphragmatic paralysis (HDP) is included. Costoclavicular brachial plexus-cervical plexus blocks (CCB-CPBs) offer comparable analgesia with lower HDP risk, yet local anesthetic volume issues can affect outcomes. In patients undergoing arthroscopic shoulder surgeries under general anesthesia with CCB-CPBs, the aim is to determine the optimal dose of ropivacaine for postoperative analgesia while avoiding hemidiaphragmatic paralysis (HDP). METHODS AND ANALYSIS: This trial will be a prospective, single-arm, double-blind dose finding study. We plan to enroll 40 patients who will be scheduled to undergo arthroscopic shoulder surgeries under anesthesia that combines general anesthesia with CCB-CPBs. The volume of the local anesthetic will be determined by adopting the Up-and-Down sequential allocation study design. The primary outcome will be the numerical rating scale (NRS) scores of the patients prior to their departure from the post-anesthesia care unit (PACU). As for the secondary outcomes, they will include the ipsilateral diaphragmatic excursion, the characteristics of the sensory-motor block, the occurrence of complications, as well as the consumption of fentanyl during the operation. ETHICS AND DISSEMINATION: Approval for the protocol of this study was granted by the Ethics Committee of Ningbo No. 6 Hospital in Zhejiang Province, China, on July 29, 2024 (Approval No. 2024-67L). Once the study is completed, we are committed to guaranteeing that the results will be accessible to the public, irrespective of the outcome. This will involve either publishing them in an appropriate journal or presenting them orally at academic conferences.
trial registrationTrial registration number ChiCTR2400090292.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.