Evidence map›Paper›PMID 40377994›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

An RNA-binding regulatory cascade controls the switch from proliferation to differentiation in the

Devon E Harris, Jongmin J Kim, Sarah R Stern, Hannah M Vicars, Neuza R Matias, Lorenzo Gallicchio, Catherine C Baker, Margaret T Fuller

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Devon E HarrisDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305.
Jongmin J KimDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-1836-2064
Sarah R SternDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305.
Hannah M VicarsDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305.
Neuza R MatiasDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305.
Lorenzo GallicchioDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305.
Catherine C BakerDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305.
Margaret T FullerDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-3804-4987

Funding

GENETICS TRAINING PROGRAM FOR PHD CANDIDATEST32GM007790 · NIGMS · STANFORD UNIVERSITY · PI BRUNET, ANNE, KINGSLEY, DAVID M · 1985 to 2020
$12.8M
Regulation of proliferation and differentiation in the male germ line adult stem cell lineageR35GM136433 · NIGMS · STANFORD UNIVERSITY · PI MARGARET T FULLER · 2020 to 2026
$5.9M
Stanford University Center for Reproductive and Stem Cell biologyU54HD068158 · NICHD · STANFORD UNIVERSITY · PI FULLER, MARGARET T · 2011 to 2013
$5.0M
Conserved regulation of the switch from proliferation to differentiation in the germ line stem cell lineageR01GM122951 · NIGMS · STANFORD UNIVERSITY · PI FULLER, MARGARET T · 2018 to 2020
$956k
Nikon A1Rsi resonant spectral confocal microscopeS10OD010580 · OD · STANFORD UNIVERSITY · PI FULLER, MARGARET T · 2013 to 2013
$377k
HHS | NIH | National Center for Research Resources (NCRR) 1S10OD010580-01A1HHS | NIH | National Institute of General Medical Sciences (NIGMS) 1R01GM122951HHS | NIH | National Institute of General Medical Sciences (NIGMS) 1R35GM136433HHS | NIH | National Institute of General Medical Sciences (NIGMS) 5T32GM007790NICHD NIH HHS U54 HD068158NIGMS NIH HHS R01 GM122951NIGMS NIH HHS R35 GM136433NIGMS NIH HHS T32 GM007790NIH HHS S10 OD010580
6 · The paper itself

Abstract

The switch from precursor cell proliferation to onset of differentiation in adult stem cell lineages must be carefully regulated to produce sufficient progeny to maintain and repair tissues, yet prevent overproliferation that may enable oncogenesis. In the

Indexed as

Cell DifferentiationCell LineageCell ProliferationDrosophila melanogasterDrosophila ProteinsRNA-Binding ProteinsSpermatogoniaAnimalsMaleMitosisSpermatocytesbam protein, DrosophilaDrosophila ProteinsRNA-Binding Proteinsadult stem cellsdifferentiationproliferationRNA-binding proteinsspermatogonia

Identifiers

PMID40377994
PMCPMC12107169

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.