ArticleProceedings of the National Academy of Sciences of the United States of America2025
Myelin sheaths can act as compact temporary oxygen storage units as modeled by an electrical RC circuit model.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Reply to Panfoli et al.: From OProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Myelination sustains axonal bioenergetics by storing and consuming oxygen for aerobic metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Metabolic interactions in the brain: the crucial roles of neurons, astrocytes, and microglia in health and disease.Frontiers in neuroscience · 2026Review
- Where Is the Oxygen? The Mirage of Non-Oxidative Glucose Consumption During Brain Activity.NeuroSci · 2025Review
- Flexoelectricity and the fluctuations of (active) living cells: Implications for energy harvesting, ion transport, and neuronal activity.PNAS nexus · 2025Article
- Spatiotemporal dynamics of local anesthetic diffusion in nerve revealed by a 2D computational model.Biophysical journal · 2025Article
- Myelin sheaths can act as compact temporary oxygen storage units as modeled by an electrical RC circuit model.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Validation of a Coarse-Grained Martini 3 Model for Molecular Oxygen.Journal of chemical theory and computation · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
Oxygen is crucial for mitochondrial energy production in neurons and is efficiently stored and transported within the hydrophobic core of phospholipid bilayers. Using a diffusive model derived from molecular dynamics simulations, we demonstrate that oxygen storage in a bilayer follows first-order kinetics, which can be effectively represented by an RC (resistor-capacitor) circuit. For myelin, with multiple bilayers, oxygen transport is modeled through a ladder network of RC circuits, where oxygen permeation resistance and oxygen storage capacity scale linearly with bilayer count. Meanwhile, the characteristic time constant scales quadratically with myelin thickness, e.g. enhancing the characteristic time constant from 30 ns for one 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) bilayer to 506
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