Evidence map›Paper›PMID 40377908›Full record

ArticleACS applied materials & interfaces2025

Yoda1-Loaded Microfibrous Scaffolds Accelerate Osteogenesis through Piezo1-F-Actin Pathway-Mediated YAP Nuclear Localization and Functionalization.

Junzheng Liu, Zijie Meng, Jidong Song, Jiaming Yu, Qin Guo, Jiahao Zhang, Shuo Wang, Yulin Wang, Zhennan Qiu, Xinyi Zhang and 2 more

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
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  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Junzheng LiuComprehensive Orthopedics Department, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P. R. China.ORCID 0000-0001-6852-9697
Zijie MengFrontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China.
Jidong SongComprehensive Orthopedics Department, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P. R. China.
Jiaming YuShaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, P. R. China.
Qin GuoComprehensive Orthopedics Department, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P. R. China.
Jiahao ZhangComprehensive Orthopedics Department, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P. R. China.
Shuo WangShaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, P. R. China.
Yulin WangComprehensive Orthopedics Department, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P. R. China.
Zhennan QiuState Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an 710049, P. R. China.
Xinyi ZhangComprehensive Orthopedics Department, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P. R. China.
Jiankang HeState Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an 710049, P. R. China.ORCID 0000-0002-9386-5833
Wei WangComprehensive Orthopedics Department, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Yoda1 has been recognized as an effective pharmacological intervention for the treatment of critical bone defects. However, the local delivery strategy of Yoda1 is uncommon, and the underlying mechanism through which Yoda1 enhances osteogenesis has been poorly investigated. Here, we propose utilizing electrohydrodynamic (EHD)-printed microfibrous scaffolds as a drug carrier for loading Yoda1 through a polydopamine (PDA) coating, and the synthetic mechanisms for enhancing bone regeneration are explored. Yoda1 was successfully loaded on the surface of the EHD-printed microfibrous scaffolds with the assistance of PDA. The results of

Indexed as

ActinsOsteogenesisTissue ScaffoldsAnimalsBone RegenerationHumansIndolesMicePolymersYAP-Signaling ProteinsActinsIndolespolydopaminePolymersYAP-Signaling Proteinsbone regenerationelectrohydrodynamic printingosteogenesisPiezo1YAPYoda1

Identifiers

PMID40377908
PMCPMC12123560

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.