ArticleAging clinical and experimental research2025
Clinical significance of serum irisin, 25(OH)D3 and albumin in older adults with chronic disease and sarcopenia.
Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The association between the red blood cell distribution width to albumin ratio with all-cause and cause-specific mortality in patients with hyperlipidemia: a cohort study based on NHANES 1999-2018.Irish journal of medical science · 2026Article
- Irisin ameliorates age-associated skeletal muscle atrophy in mice: potential involvement of iron overload and SIRT1/p53 pathway.Journal of physiology and biochemistry · 2025Article
- Dietary and Physical Activity Correlates of Muscle Mass in 60-65-Year-Old Seniors: A Gender-Specific Analysis.Nutrients · 2025Article
- Association between albumin-bilirubin score and sarcopenia in middle-aged Americans: a cross-sectional study.Frontiers in nutrition · 2025Article
- The association between nutritional assessment tools and CT-assessed sarcopenia in abdominal aortic aneurysm: a cross-sectional study.Frontiers in nutrition · 2025Article
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Authors and funding
5 authors.
Funding
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Abstract
backgroundSarcopenia, characterized by progressive muscle mass and strength decline, poses a significant health challenge among older adults, especially those with chronic diseases. Our study aims to evaluate the combined diagnostic potential of irisin, 25(OH)D3, and albumin for sarcopenia in older patients with chronic conditions.
methodsA cohort of 393 older patients with chronic diseases, including 117 diagnosed with sarcopenia were included. Fasting blood samples were collected, and serum biomarkers (25(OH)D3, albumin, and irisin) were measured using automated biochemical analyzers and enzyme-linked immunosorbent assay to evaluate nutritional and muscle-related parameters.
resultsThe prevalence of sarcopenia was higher among patients aged 80 or older compared to younger age groups in our study population. Strong associations were observed between sarcopenia and osteoporosis, tumors, and risk of malnutrition. Serum irisin, 25(OH)D3, and albumin levels were significantly lower in sarcopenic patients. Individual biomarkers displayed diagnostic potential, and a combined biomarker test showed superior accuracy. Multivariate logistic regression identified age, osteoporosis, malnutrition, and fatigue as independent risk factors, while higher serum biomarker levels correlated with reduced sarcopenia risk. Positive correlations were observed between serum biomarkers and sarcopenia severity indicators.
conclusionsThis study highlights the potential of irisin, 25(OH)D3, and albumin as diagnostic and prognostic tools for sarcopenia in older patients with chronic diseases, contributing to early detection and intervention strategies to enhance their quality of life.
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