Evidence map›Paper›PMID 40377748›Full record

ReviewJournal of neurology2025

Hearing impairment and dementia: cause, catalyst or consequence?

Benjamin A Levett, Avinash Chandra, Jessica Jiang, Nehzat Koohi, Dale Sharrad, Lucy B Core, Jeremy C S Johnson, Madison Tutton, Tim Green, Dona M P Jayakody and 6 more

Erratum issuedAbstract readReview
In one paragraph

Review in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Non-verbal dichotic listening: A new cognitive hearing test for dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Benjamin A LevettDementia Research Centre, UCL Institute of Neurology, Queen Square, UCL, 8-11 Queen Square, London, WC1N 3AR, UK.
Avinash ChandraCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Jessica JiangDementia Research Centre, UCL Institute of Neurology, Queen Square, UCL, 8-11 Queen Square, London, WC1N 3AR, UK.
Nehzat KoohiDepartment of Clinical and Movement Neurosciences, Institute of Neurology, UCL, 33 Queen Square, London, WC1N 3BG, UK.
Dale SharradNational Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK.
Lucy B CoreDementia Research Centre, UCL Institute of Neurology, Queen Square, UCL, 8-11 Queen Square, London, WC1N 3AR, UK.
Jeremy C S JohnsonDementia Research Centre, UCL Institute of Neurology, Queen Square, UCL, 8-11 Queen Square, London, WC1N 3AR, UK.
Madison TuttonEargym Ltd, 63-66 Hatton Garden, London, EC1N 8LE, UK.
Tim GreenEargym Ltd, 63-66 Hatton Garden, London, EC1N 8LE, UK.
Dona M P JayakodyUniversity of Western Australia, 35 Stirling Hwy, Crawley, WA, 6009, Australia.
Jin-Tai YuHuashan Hospital, Fudan University, 2 Wulumuqi Road, Shanghai, 200040, China.
Iracema LeroiGlobal Brain Health Institute, Trinity College Dublin, 42A Pearse Street, Dublin, D02 R123, Ireland.
Charles R MarshallCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Doris-Eva BamiouNational Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK.
Chris J D Hardy *Dementia Research Centre, UCL Institute of Neurology, Queen Square, UCL, 8-11 Queen Square, London, WC1N 3AR, UK.
Jason D Warren *Dementia Research Centre, UCL Institute of Neurology, Queen Square, UCL, 8-11 Queen Square, London, WC1N 3AR, UK. jason.warren@ucl.ac.uk.ORCID http://orcid.org/0000-0002-5405-0826

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The relationship between hearing impairment and dementia has attracted significant attention, the 2024 Lancet Commission report identifying hearing loss as the largest modifiable risk factor for dementia from mid-life. The nature of this linkage between dementia and hearing remains unclear and is likely to be complex. In principle, hearing impairment could cause (directly promote), catalyze (amplify) or be a consequence of neurodegenerative pathology and cognitive decline. Here we use this framework to examine different lines of evidence for the association between hearing impairment and dementia, and consider how this evidence speaks to potential mechanisms and treatment implications. We conclude by considering practical clinical implications for management of patients with hearing impairment and dementia, the potential role for central hearing tests as 'auditory biomarkers' of dementia, and the need for further collaborative and mechanistically motivated research in this area.

Indexed as

DementiaHearing LossHumansAlzheimer’s diseaseAuditoryBiomarkersDementiaFrontotemporal dementiaHearing

Identifiers

PMID40377748
PMCPMC12084262

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.