Evidence map›Paper›PMID 40377740›Full record

ArticleMolecular biology reports2025

The association of TCF7L2 gene polymorphisms, rs12255372 and rs7903146, with type 2 diabetes mellitus in the Jordanian population.

Nour Ghosheh, Randa G Naffa, Safaa Mashal, Sawsan Al-Khalayfa, AbdelKader Hamdi Battah, Bilal Azab

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Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

  1. Integrative Clinical and Functional Characterization of theDiagnostics (Basel, Switzerland) · 2026
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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Nour GhoshehDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, University of Jordan, Queen Rania St, PO Box: 13617, Amman, 11942, Jordan.
Randa G NaffaDepartment of Basic Dental Sciences, Faculty of Dentistry, Al-Ahliyya Amman University, Amman, Jordan.
Safaa MashalDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, University of Jordan, Queen Rania St, PO Box: 13617, Amman, 11942, Jordan.
Sawsan Al-KhalayfaDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, University of Jordan, Queen Rania St, PO Box: 13617, Amman, 11942, Jordan.
AbdelKader Hamdi BattahDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, University of Jordan, Queen Rania St, PO Box: 13617, Amman, 11942, Jordan.
Bilal AzabDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, University of Jordan, Queen Rania St, PO Box: 13617, Amman, 11942, Jordan. b.azab@ju.edu.jo.

Funding

Deanship of Scientific Research, University of Jordan 1331/2021/67
6 · The paper itself

Abstract

backgroundType 2 diabetes mellitus (T2D) is one of the biggest health concerns of our time. T2D prevalence is expected to reach 1.9 million Jordanians by 2050. Owing to this sharp increase, Jordanians should understand genetic risk factors for this disease. One of the strongest reported single nucleotide polymorphisms (SNPs) associated with T2D is located in the transcription factor 7-like 2 (TCF7L2) gene, particularly rs12255372 and rs7903146. Despite this, contradictory results suggesting no association with T2D were found across ethnicities. Therefore, this study investigated the association of rs12255372 and rs7903146 with T2D in Jordanians. METHODS AND

resultsFor this case-control study, 301 non-diabetic healthy controls and 301 patients with T2D were genotyped for rs12255372 and rs7903146 using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). A significant development in T2D was demonstrated in rs12255372 and rs7903146. The risk allele for both single nucleotide polymorphisms is the T allele. The p-value ≤ 0.001 reflects a significant difference between the control group and the T2D group. Moreover, the combined effect of rs12255372 and rs7903146 showed statistical significance with a p-value ≤ 0.001.

conclusionOur study suggests that TCF7L2 gene polymorphisms (rs12255372 and rs7903146) are predisposing risk factors for T2D in the Jordanian population.

Indexed as

Diabetes Mellitus, Type 2Polymorphism, Single NucleotideTranscription Factor 7-Like 2 ProteinAdultAgedAllelesCase-Control StudiesFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansJordanMaleMiddle AgedTCF7L2 protein, humanTranscription Factor 7-Like 2 ProteinJordanian populationrs12255372rs7903146Transcription factor 7-like 2 (TCF7L2)Type 2 diabetes mellitus

Identifiers

PMID40377740

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