Evidence map›Paper›PMID 40377734›Full record

ArticleArchives of virology2025

Evaluation of in vitro growth and pathogenicity in mice of intra-genotype chimeric strains of genotype IV Japanese encephalitis virus.

Shigeru Tajima, Astri Nur Faizah, Daisuke Kobayashi, Kris Cahyo Mulyatno, Sri Subekti, Maria Inge Lusida, Yasuko Mori, Haruhiko Isawa, Kyoko Sawabe, Chang-Kweng Lim

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shigeru TajimaDepartment of Virology I, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo, 162-8640, Japan. stajima@niid.go.jp.ORCID http://orcid.org/0000-0002-1981-9062
Astri Nur FaizahDepartment of Medical Entomology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo, 162-8640, Japan.
Daisuke KobayashiDepartment of Medical Entomology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo, 162-8640, Japan.
Kris Cahyo MulyatnoLaboratory of Entomology, Institute of Tropical Diseases, Universitas Airlangga, Surabaya, East Java, Indonesia.
Sri SubektiLaboratory of Entomology, Institute of Tropical Diseases, Universitas Airlangga, Surabaya, East Java, Indonesia.
Maria Inge LusidaLaboratory of Entomology, Institute of Tropical Diseases, Universitas Airlangga, Surabaya, East Java, Indonesia.
Yasuko MoriDivision of Clinical Virology, Center for Infectious Diseases, Kobe University, Kobe, Hyogo, Japan.
Haruhiko IsawaDepartment of Medical Entomology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo, 162-8640, Japan.
Kyoko SawabeDepartment of Medical Entomology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo, 162-8640, Japan.
Chang-Kweng LimDepartment of Virology I, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo, 162-8640, Japan.

Funding

Japan Agency for Medical Research and Development JP19fm0108004Japan Agency for Medical Research and Development JP20fk0108067Japan Agency for Medical Research and Development JP23fk0108656
6 · The paper itself

Abstract

Two recombinant intra-genotype chimeric genotype IV Japanese encephalitis virus (GIV JEV) strains with the 5' non-coding and C-prM-E regions (5NCME) of the Vietnamese strain VN113 or the Australian strain sw-22-00722-11.Qld (sw-22) were produced using the Indonesian strain 19CxBa-83-Cv as a backbone. The three strains exhibited similar plaque morphology and growth rate in Vero cells. The virus with sw-22 5NCME was less neuroinvasive than 19CxBa-83-Cv, but the virulence of the virus with VN113 5NCME was similar to that of 19CxBa-83-Cv. Thus, our results suggest that the pathogenicity of sw-22 might be lower than that of the other two GIV JEV isolates.

Indexed as

Encephalitis, JapaneseEncephalitis Virus, JapaneseAnimalsChlorocebus aethiopsGenotypeMiceRecombination, GeneticVero CellsVirulence

Identifiers

PMID40377734

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.