Evidence map›Paper›PMID 40377719›Full record

SynthesisArchives of dermatological research2025

The lip flip: a systematic review of botulinum toxin lip augmentation.

Chase A Pitchford, Andrew S Desrosiers, Stanislav N Tolkachjov

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Archives of dermatological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Chase A Pitchford *Mark Allen Everett Department of Dermatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Andrew S Desrosiers *Department of Dermatology, Geisinger Medical Center, Danville, PA, USA.
Stanislav N TolkachjovMohs Micrographic & Reconstructive Surgery, Epiphany Dermatology, Dallas, TX, USA. stan.tolkachjov@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cosmetic use of botulinum toxin type-A (BTA) has expanded to include the "lip flip" procedure, which enhances lip contour and fullness without adding volume. This minimally invasive and cost-effective technique offers a favorable safety profile for patients seeking subtle lip enhancement. This review systematically examines the technique, clinical outcomes, and safety of the lip flip through neuromodulation with BTA. A comprehensive literature search was conducted using PubMed and Ovid, identifying 48 articles, of which seven met inclusion criteria detailing injection sites and dosages. The procedure typically involves injecting 4-6 units of BTA into the orbicularis oris muscle, resulting in consistent upper lip eversion and improved contour. Patients report high satisfaction and minimal downtime, with mild and transient side effects such as difficulty whistling or drinking through straws resolving within weeks.

Indexed as

Botulinum Toxins, Type ACosmetic TechniquesLipNeuromuscular AgentsFacial MusclesHumansInjections, IntramuscularPatient SatisfactionSkin AgingTreatment OutcomeBotulinum Toxins, Type ANeuromuscular AgentsBotulinum toxinCosmetic dermatologyLip flipNeuromodulatorPerioral neuromodulation

Identifiers

PMID40377719

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.