Evidence map›Paper›PMID 40377699›Full record

ArticleAmerican journal of respiratory and critical care medicine2025

Human Sputum Microbiome Composition and Sputum Inflammatory Cell Profiles Are Altered with Controlled Wood Smoke Exposure as a Model for Wildfire Smoke.

Catalina Cobos-Uribe, Radhika Dhingra, Martha A Almond, Neil E Alexis, David B Peden, Jeffrey Roach, Meghan E Rebuli

Abstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Exploratory analysis of the impact of sex on sputum proteomic response to inhaled wood smoke in humans.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Article
  3. Article
  4. Environmental Exposures and the Microbiome: Where There Is Smoke, Is There Fire?American journal of respiratory and critical care medicine · 2025
    Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Catalina Cobos-UribeCurriculum in Toxicology & Environmental Medicine.ORCID 0000-0002-6671-0780
Radhika DhingraEnvironmental Sciences and Engineering Department, Gillings School of Global Public Health.ORCID 0000-0003-0202-1860
Martha A AlmondCenter for Environmental Medicine, Asthma, and Lung Biology.
Neil E AlexisCenter for Environmental Medicine, Asthma, and Lung Biology.ORCID 0000-0002-9417-8269
David B PedenCenter for Environmental Medicine, Asthma, and Lung Biology.ORCID 0000-0003-4526-4627
Jeffrey RoachUNC Microbiome Core, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0001-9817-5877
Meghan E RebuliCurriculum in Toxicology & Environmental Medicine.ORCID 0000-0003-1918-2257

Funding

North Carolina Translational and Clinical Sciences Institute (NC TraCS)UM1TR004406 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NICHOLAS J SHAHEEN · 2023 to 2026
$37.5M
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Venkata Saroja Voruganti · 1999 to 2026
$31.6M
PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT S. SANDLER · 1985 to 2026
$30.5M
TOXICOLOGYT32ES007126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ILONA JASPERS, Bernard E. Weissman · 1985 to 2026
$13.0M
Gamma tocopherol chemoprevention of wood smoke PM2.5-induced airway inflammationR01ES025124 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PEDEN, DAVID B. · 2016 to 2020
$2.8M
Impact of sex on respiratory response to wood smoke exposureK01ES032837 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI REBULI, MEGHAN ELIZABETH · 2022 to 2024
$457k
Woodsmoke-induced disruption of Nasal Microbiome and Cytokine ProfilesR21ES032928 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DHINGRA, RADHIKA, REBULI, MEGHAN ELIZABETH · 2021 to 2022
$422k
The respiratory microbiome and its role in the host response to wood smokeF31ES036437 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COBOS-URIBE, CATALINA · 2024 to 2024
$40k
EPA EPA-ORD-CPHEA-2021-01NCATS NIH HHS UM1 TR004406NCATS NIH HHS UM1TR004406NIDDK NIH HHS P30 DK034987NIDDK NIH HHS P30DK034987NIDDK NIH HHS P30 DK056350NIEHS NIH HHS F31 ES036437NIEHS NIH HHS F31ES036437NIEHS NIH HHS K01 ES032837NIEHS NIH HHS R01 ES025124NIEHS NIH HHS R21 ES032928NIEHS NIH HHS T32 ES007126
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

MicrobiotaSmokeSputumWildfiresWoodAdultFemaleHumansMaleMiddle AgedNeutrophilsSmokemicrobiotasmokesputumwildfireswood

Identifiers

PMID40377699
PMCPMC12619000

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.