ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2025
Urinary Levels of Endocrine-Disrupting Chemicals and Breast Density in Young Women.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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8 authors.
Funding
Abstract
backgroundEndocrine-disrupting chemicals (EDC) found in many household and personal care products have hormonal properties and effects on the mammary gland. It is unclear whether urinary concentrations of EDCs are associated with higher percent breast density, a major risk factor of breast cancer.
methodsWe conducted a cross-sectional study of 97 college-aged women. We quantified individual levels of bisphenol A, bisphenol S, bisphenol F, triclosan, triclocarban, 3-benzophenone, seven phthalate metabolites, four parabens, and two other phenols in three 24-hour urine samples combined into a single pooled sample. Each woman had non-enhanced MRI to assess percent breast density. Associations between estimated concentrations of individual EDCs and percent breast density were analyzed using adjusted linear regression.
resultsThere was no evidence of a statistically significant increase in mean percent breast density in the middle or highest tertile for any EDC measured. There was a suggestion that the mean percent breast density was elevated in individuals in the middle and highest tertile levels of ethyl paraben compared with those in the lowest tertile, with a relative increase in mean percent breast density of 16% (β = 1.16; 95% CI, 0.92-1.46) in tertile 2 and 24% (β = 1.24; 95% CI, 0.99-1.57) in tertile 3, relative to tertile 1 (Ptrend = 0.07). Similar trends in percent breast density were observed for methylparaben, propylparaben, and butylparaben.
conclusionsUrinary levels of EDCs were not associated with percent breast density in college-aged women. IMPACT: The estimated effect of EDCs on the breast tissue of young women is unclear and warrants larger studies.
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