ArticleExperimental brain research2025
Neural correlates of concern about falling in multiple sclerosis: resting-state functional connectivity in amygdala-hippocampal and amygdala-cerebellar circuits.
Article in Experimental brain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Associating Resting-State functional connectivity and improvements in reactive balance in Parkinson's Disease.Neuroscience letters · 2026Article
- Motor, Cognitive, Psychological, and Neural Predictors of Concern About Falling in Persons With Multiple Sclerosis.Neurorehabilitation and neural repair · 2026Article
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6 authors.
Funding
Abstract
backgroundConcern about falling (CAF) is common in multiple sclerosis (MS), impacting motor function, cognition, and emotional well-being. However, the underlying neural correlates remain understudied. Given the multifactorial nature of CAF, we hypothesized that neural correlates may involve interactions between brain regions involved in emotional (e.g., amygdala), motor (e.g., cerebellum), and cognitive functions (e.g., hippocampus). This study explored associations between CAF and resting-state functional connectivity (FC) in amygdala-hippocampal and amygdala-cerebellar circuits in MS.
methodsParticipants with relapsing-remitting MS completed the Falls Efficacy Scale-International to assess CAF, followed by a functional MRI scan. Region of interest (ROI)-to-ROI analyses examined associations between CAF and FC in amygdala-hippocampal and amygdala-cerebellar circuits. Significant connections were identified using false discovery rate (FDR) correction at α = 0.05.
resultsForty-one individuals participated in our study. CAF was significantly associated with greater amygdala-hippocampal FC (T(39) ≥ 3.76, q ≤ 0.001) and lower amygdala-cerebellar FC (T(39) ≤ -2.52, q ≤ 0.026).
conclusionThese findings highlight distinct neural patterns linked to CAF in MS. Higher CAF was associated with greater amygdala-hippocampal connectivity, suggesting that neural circuits underlying fear-related memories and emotional processing may play a crucial role in perceived fall risk. In contrast, lower amygdala-cerebellar connectivity in individuals with heightened CAF may reflect diminished integration of emotional and motor output, potentially compromising the ability to assess environmental hazards and situations where falls are likely to occur. Further understanding these neural underpinnings may help develop targeted interventions to reduce CAF and its negative impact on people with MS.
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