Evidence map›Paper›PMID 40377514›Full record

ArticleJACC. Case reports2025

Leadless Atrial Pacing Targeting Bachmann's Bundle for Atrial Resynchronization.

Zachary Hollis, Eunice Yang, Kyungmoo Ryu, Leyla Sabet, Gaurav A Upadhyay, Brett Atwater

Abstract readCase Reports
In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  7. Leadless pacemaker implantation in the region of Bachmann's bundle: initial results.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zachary HollisInova Schar Heart and Vascular, Falls Church, Virginia, USA. Electronic address: zachary.hollis@inova.org.
Eunice YangInova Schar Heart and Vascular, Falls Church, Virginia, USA; Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Kyungmoo RyuAbbott Medical, Sylmar, California, USA.
Leyla SabetAbbott Medical, Sylmar, California, USA.
Gaurav A UpadhyayUniversity of Chicago Medicine, Chicago, Illinois, USA.
Brett AtwaterInova Schar Heart and Vascular, Falls Church, Virginia, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLeadless pacemakers have transformed pacing by reducing risk for infection and lead-related complications. The feasibility of achieving leadless Bachmann's bundle area pacing (BBAP) for atrial resynchronization is not known. FIRST-IN-HUMAN SUMMARY: A 49-year-old woman with sinus node dysfunction and interatrial conduction delay underwent leadless atrial pacemaker targeting Bachmann's bundle (BB). Using intracardiac echocardiography and electrographic mapping, the pacemaker was positioned at the BB region. Reduced right atrium-to-lateral left atrium conduction time and paced P wave duration were confirmed. DISCUSSION: Right atrial appendage pacing may exacerbate interatrial conduction delay and promote atrial fibrillation. BBAP using a leadless atrial pacemaker, in contrast, has been shown to enhance atrial synchrony. NOVELTY: This case demonstrates the first-in-human permanent implantation of a leadless pacemaker in the BB area, providing a strategy for leadless atrial resynchronization. TAKE-HOME MESSAGE: Leadless BBAP may offer a physiological approach to atrial conduction system pacing by improving atrioventricular dromotropy and reducing subsequent risk for atrial fibrillation.

Indexed as

atrial fibrillationatrial resynchronizationbachmann's bundle pacinginteratrial conduction delayleadless atrial pacingsinus node dysfunction

Identifiers

PMID40377514
PMCPMC12441421

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.