Evidence map›Paper›PMID 40377420›Full record

ArticleRadiology. Imaging cancer2025

Safety, Efficacy, and Adjacent-level Fracture Risk Following Vertebral Augmentation and Radiofrequency Ablation for the Treatment of Spine Metastases in Patients with Cancer.

Jeremiah Stringam, Koustav Pal, Andrew Niekamp, Rahim Jiwani, Iwan Paolucci, Joshua D Kuban, Zeyad Metwalli, Steven Huang, Peiman Habibollahi, Stephen Chen and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology. Imaging cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jeremiah Stringam *Department of Interventional Radiology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1471, Houston, TX 77030-4009.
Koustav Pal *Department of Interventional Radiology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1471, Houston, TX 77030-4009.ORCID 0000-0002-0777-2260
Andrew NiekampMiami Cancer Institute, Baptist Health South Florida, Miami, Fla.
Rahim JiwaniDepartment of Interventional Radiology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1471, Houston, TX 77030-4009.
Iwan PaolucciDepartment of Interventional Radiology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1471, Houston, TX 77030-4009.
Joshua D KubanDepartment of Interventional Radiology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1471, Houston, TX 77030-4009.
Zeyad MetwalliDepartment of Interventional Radiology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1471, Houston, TX 77030-4009.
Steven HuangDepartment of Interventional Radiology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1471, Houston, TX 77030-4009.
Peiman HabibollahiDepartment of Interventional Radiology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1471, Houston, TX 77030-4009.
Stephen ChenDepartment of Interventional Radiology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1471, Houston, TX 77030-4009.
Steven YevichDepartment of Interventional Radiology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1471, Houston, TX 77030-4009.
Milan PatelDepartment of Interventional Radiology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1471, Houston, TX 77030-4009.
Sumit K SubudhiDepartment of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Tex.
Matthew CampbellDepartment of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Tex.
Amol GhiaDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Tex.
Claudio TatsuiDepartment of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, Tex.
Rahul A ShethDepartment of Interventional Radiology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1471, Houston, TX 77030-4009.ORCID 0000-0001-9615-8985

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose To evaluate the safety and efficacy of vertebral augmentation (VA) and radiofrequency ablation (RFA) for treating pathologic spinal fractures in patients with cancer and adjacent fracture risk following treatment. Materials and Methods This single-institution retrospective study, conducted from January 2017 to September 2020, included patients with cancer who underwent percutaneous VA with or without spine RFA for pathologic spine compression fractures. The primary outcome was pain reduction, assessed using the 10-point visual analog scale before the procedure, at first follow-up, and 2-4 weeks after the procedure. Logistic regression was performed to identify factors associated with epidural cement leak. Results A total of 638 spinal levels in 335 patients (median age, 65 years [IQR, 58-74 years]; 147 female, 188 male) were treated. Epidural tumor and retropulsion of bone fragments were present in 15% (93 of 638) and 13% (81 of 638) of treated levels, respectively, while posterior wall erosion was observed in 30% (190 of 638). Substantial pain improvement (greater than two-point reduction) occurred in 81% (519 of 638) of cases. Factors associated with decreased risk of epidural cement leak included RFA (42% no leak vs 38% leak,

Indexed as

Fractures, CompressionRadiofrequency AblationSpinal FracturesSpinal NeoplasmsVertebroplastyAgedFemaleHumansMaleMiddle AgedPain MeasurementRetrospective StudiesTreatment OutcomeAblation TechniquesKyphoplastyVertebroplasty

Identifiers

PMID40377420
PMCPMC12130721

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.