Observational studyAmerican journal of hypertension2025
Plasma Reactive Dicarbonyls Are Not Independently Associated With Arterial Stiffness: The Maastricht Study.
Observational study in American journal of hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundArterial stiffness is a strong predictor of cardiovascular diseases and all-cause mortality. Increased concentrations of highly reactive dicarbonyl compounds-methylglyoxal (MGO), glyoxal (GO), and/or 3-deoxyglucosone (3-DG)-may cause arterial stiffening via formation of advanced glycation end products, triggering maladaptive responses in vascular tissue, e.g., elastin degradation and collagen cross-linking. Therefore, we investigated in the population-based Maastricht study whether plasma MGO, GO, and 3-DG concentrations were cross-sectionally associated with carotid-to-femoral pulse wave velocity (cfPWV) and local carotid stiffness measures: pulse wave velocity (cPWV), and Young's elastic modulus (cYEM) using standardized main variables.
methodsFasting dicarbonyl concentrations were determined by ultra-performance liquid chromatography tandem mass spectrometry in EDTA plasma collected from 2,275 participants (age 60 ± 8 years, mean ± SD; 49% women, 605 (27%) with type 2 diabetes mellitus) of the Maastricht Study, an observational, population-based cohort study. Cross-sectional associations were assessed using multivariable linear regression analysis adjusting for age, sex, mean arterial pressure (MAP), heart rate, lifestyle factors, and medication. Since arterial stiffness measures are intrinsically pressure dependent, we additionally assessed the associations with pressure-corrected counterparts, instead of statistically correcting for MAP.
resultsFasting dicarbonyl concentrations were associated with arterial stiffness measures (greater cfPWV, cPWV, and cYEM) in most crude models, but not in adjusted models. The use of pressure-corrected metrics did not materially change the association of interest.
conclusionsFasting plasma concentrations of either MGO, GO, or 3-DG are not independently associated with arterial stiffness in this cross-sectional analysis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.