1,2-Dihydropyrimidine synthesis

Rachel J Dunscomb, Connor W Frye, Xavier Murray, Ian A Tonks

Abstract read

In one paragraph

Article in Chemical communications (Cambridge, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rachel J DunscombDepartment of Chemistry, University of Minnesota-Twin Cities, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA. itonks@umn.edu.ORCID http://orcid.org/0000-0003-4302-0522

Connor W FryeDepartment of Chemistry, University of Minnesota-Twin Cities, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA. itonks@umn.edu.

Xavier MurrayDepartment of Chemistry, University of Minnesota-Twin Cities, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA. itonks@umn.edu.

Ian A TonksDepartment of Chemistry, University of Minnesota-Twin Cities, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA. itonks@umn.edu.ORCID http://orcid.org/0000-0001-8451-8875

Funding

Ti-Catalyzed Oxidative Amination ReactionsR35GM119457 · NIGMS · UNIVERSITY OF MINNESOTA · PI Ian Albert Tonks · 2016 to 2026

$4.4M

Upgrade of a 500 MHz NMR Spectrometer for Applications in Biomedical ResearchS10OD011952 · OD · UNIVERSITY OF MINNESOTA · PI HOYE, THOMAS R. · 2012 to 2012

$378k

NIGMS NIH HHS R35 GM119457NIH HHS S10 OD011952

6 · The paper itself

Abstract

While dihydropyrimidine cores are found in a number of bioactive molecules, 1,2-dihydropyrimidine regioisomers remain relatively underexplored due to a scarcity of simple synthetic routes to access them. Here, a modular, multicomponent synthesis to 1,2-dihydropyrimidines from alkynes, nitriles, aldehydes, and Ti imido complexes is reported, proceeding through a key diazatitanacycle intermediate that was previously exploited for pyrazole and α-diimine synthesis. The 1,2-dihydropyrimidines are formed through [2+2]-cycloaddition of an aldehyde with the diazatitanacycle synthetic intermediate, followed by cycloreversion to a 1,5-diazatriene that undergoes facile electrocyclization to the 1,2-dihydropyrimidine.

Identifiers

PMID40377374

DOI10.1039/d5cc01979f

PMCPMC12151746

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.