Evidence map›Paper›PMID 40377220›Full record

ArticleJournal of intellectual disability research : JIDR2025

Cognitive and Behavioural Associations of Visual and Hearing Impairments Across the Lifespan in People With Down Syndrome, a Scoping Review.

Nicolo J Betoni, Cynthia M Okamoto, Ira T Lott, Christy L Hom

Abstract readScoping Review
In one paragraph

Article in Journal of intellectual disability research : JIDR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nicolo J BetoniSchool of Medicine, University of California, Irvine, USA.ORCID 0009-0007-4016-886X
Cynthia M OkamotoSchool of Medicine, University of California, Irvine, USA.
Ira T LottDepartment of Pediatrics & Neurology, University of California, Irvine, USA.
Christy L HomDepartment of Psychiatry & Human Behavior, University of California, Irvine, USA.

Funding

VASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHUI, HELENA CHANG · 1985 to 2019
$41.0M
UC Irvine Alzheimer's Disease Research Center Induced Pluripotent Stem Cell CoreP50AG016573 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI YASSA, MICHAEL A · 2000 to 2019
$37.0M
NIA NIH HHS AG05142NIA NIH HHS AG16573NIA NIH HHS P50 AG005142NIA NIH HHS P50 AG016573
6 · The paper itself

Abstract

backgroundHearing and visual impairments are common in individuals with Down syndrome (DS), yet it remains unclear whether sensory impairments are associated with cognitive and behavioural functioning such as language, memory and socialisation. This literature review examines those associations.

methodsA scoping review of four databases was conducted to examine associations between sensory impairments and cognitive or behavioural outcomes in individuals with DS. Study evidence was assessed based on design, sample size, assessment modalities and statistical significance.

resultsOf 1471 studies screened, 38 met inclusion criteria. Hearing impairments were associated with delays in language and motor development during infancy, lower overall cognitive ability and social communication difficulties in childhood and reduced adaptive functioning and intellectual decline in adulthood. Visual impairments were linked to learning difficulties in childhood and to declines in adaptive behaviour, visual-motor integration and cognitive performance in adulthood. Subdomains of cognitive functioning such as memory, reasoning or processing speed were not reported for adults.

conclusionUncorrected hearing and visual impairments in individuals with DS are associated with a range of cognitive and behavioural outcomes across the lifespan. The strongest associations were observed between hearing impairments and language delays in infancy and childhood, and between visual impairments and adaptive behaviour challenges in childhood and adulthood. Sensory impairments were associated with challenges in similar domains-particularly language, adaptive functioning and learning-across the lifespan. This suggests a potential continuity of these associations over time and that long-standing uncorrected impairments may be associated with reduced cognitive reserve and increased vulnerability to decline-highlighting the need for early identification and intervention.

Indexed as

Cognitive DysfunctionDown SyndromeHearing DisordersVision DisordersAdultChildComorbidityHumansbehavioural functionscognitive functionsdown syndromehearing impairmentsscoping reviewvisual impairments

Identifiers

PMID40377220
PMCPMC12418728

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.