Evidence map›Paper›PMID 40377176›Full record

ArticleEpigenetics2025

Blood transcriptomic associations of epigenetic age in adolescents.

Dennis Khodasevich, Anne K Bozack, Saher Daredia, Julianna Deardorff, Kim G Harley, Brenda Eskenazi, Weihong Guo, Nina Holland, Andres Cardenas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dennis KhodasevichDepartment of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-1412-8251
Anne K BozackDepartment of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA.
Saher DarediaDivision of Epidemiology, Berkeley Public Health, University of California, Berkeley, CA, USA.
Julianna DeardorffCenter for Environmental Research and Community Health (CERCH), Berkeley Public Health, University of California, Berkeley, CA, USA.
Kim G HarleyCenter for Environmental Research and Community Health (CERCH), Berkeley Public Health, University of California, Berkeley, CA, USA.
Brenda EskenaziCenter for Environmental Research and Community Health (CERCH), Berkeley Public Health, University of California, Berkeley, CA, USA.
Weihong GuoCenter for Environmental Research and Community Health (CERCH), Berkeley Public Health, University of California, Berkeley, CA, USA.
Nina HollandCenter for Environmental Research and Community Health (CERCH), Berkeley Public Health, University of California, Berkeley, CA, USA.
Andres CardenasDepartment of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA.

Funding

Project C: Epigenetic Effects of DDT/E and PBDEs on PubertyP01ES009605 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 1999 to 2015
$11.2M
Life-course social adversity, pesticide exposure, and cognitive outcomes among an ongoing cohort of mid-life Latina women in an under served agricultural regionR01AG069090 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TORRES, JACQUELINE MARIE · 2020 to 2024
$7.8M
DDT & PBDE exposure, puberty onset and neurodevelopment in Mexican-American girlsR01ES017054 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 2009 to 2013
$3.2M
Molecular Mechanisms of Obesity in Children Exposed to Phthalates in UteroR01ES021369 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HOLLAND, NINA T · 2013 to 2017
$3.1M
Common and Distinct Influences of Prenatal and Postnatal Early-Life Adversity on Epigenomic Trajectories in Mexican American ChildrenR01MD016595 · NIMHD · UNIVERSITY OF CALIFORNIA BERKELEY · PI Andres Cardenas, Julianna Deardorff · 2022 to 2026
$3.0M
PBDEs, DDT and Neurodevelopment in School-Aged Mexican-American ChildrenR01ES015572 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 2007 to 2010
$2.0M
PRENATAL AND POSTNATAL EXPOSURE TO ENVIRONMENTAL MIXTURES: NEURODEVELOPMENT AND DNA METHYLATION BIOMARKERSR01ES031259 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CARDENAS, ANDRES · 2020 to 2024
$1.9M
Epigenetic biomarkers of cardiovascular risk in African American WomenR01HL175681 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Andres Cardenas, Nora Franceschini · 2024 to 2026
$1.2M
Fostering Scientific and Workforce Diversity by Maintaining and Enriching the CHAMACOS Birth CohortU24ES028529 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI GUNIER, ROBERT · 2023 to 2025
$1.1M
Early life influences on Epigenetic Aging in Mexican-American childrenR03AG067064 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI HOLLAND, NINA T · 2020 to 2021
$159k
NHLBI NIH HHS R01 HL175681NIA NIH HHS R01 AG069090NIA NIH HHS R03 AG067064NIEHS NIH HHS P01 ES009605NIEHS NIH HHS R01 ES015572NIEHS NIH HHS R01 ES017054NIEHS NIH HHS R01 ES021369NIEHS NIH HHS R01 ES031259NIEHS NIH HHS U24 ES028529NIMHD NIH HHS R01 MD016595
6 · The paper itself

Abstract

Epigenetic aging in early life remains poorly characterized, and patterns of gene expression can provide biologically meaningful insights. Blood DNA methylation was measured using the Illumina EPICv1.0 array and RNA sequencing was performed in blood in 174 adolescent participants (age range: 14-15 years) from the CHAMACOS cohort. Thirteen widely used epigenetic clocks were calculated, and their associations with transcriptome-wide RNA expression were tested using the

Indexed as

AgingDNA MethylationEpigenesis, GeneticTranscriptomeAdolescentAdultFemaleHumansMaleMiddle Agedadolescentepigenetic agingEpigeneticstranscriptome

Identifiers

PMID40377176
PMCPMC12087650

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.