Evidence map›Paper›PMID 40377081›Full record

ArticleNucleic acids research2025

ClusterONE Web: a tool for discovering and analyzing overlapping protein complexes.

Marcelo Baez, Ruben Jimenez, Luca Cernuzzi, Alberto Paccanaro

Abstract read
In one paragraph

Article in Nucleic acids research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Marcelo BaezEscola de Matemática Aplicada, Fundação Getúlio Vargas, Rio de Janeiro 22250-145, Brazil.ORCID 0009-0001-3135-1087
Ruben JimenezEscola de Matemática Aplicada, Fundação Getúlio Vargas, Rio de Janeiro 22250-145, Brazil.ORCID 0000-0001-8577-351X
Luca CernuzziUniversidad Católica, "Nuestra Señora de la Asunción", Asunción 001303, Paraguay.ORCID 0000-0001-7803-1067
Alberto PaccanaroEscola de Matemática Aplicada, Fundação Getúlio Vargas, Rio de Janeiro 22250-145, Brazil.ORCID 0000-0001-8059-1346

Funding

Biotechnology and Biological Sciences Research Council BB/F00964X/1Biotechnology and Biological Sciences Research Council BB/K004131/1Biotechnology and Biological Sciences Research Council BB/M025047/1Consejo Nacional de Ciencia y Tecnología PINV01-108Consejo Nacional de Ciencia y Tecnología PINV01-719Conselho Nacional de Desenvolvimento Científico e Tecnológico 311181/2022-8Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/201.079/2021Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/204.352/2024Fundação Getulio VargasMedical Research Council MR/T001070/1National Science Foundation Advances in Bioinformatics 1660648Royal HollowayUniversity of London
6 · The paper itself

Abstract

Protein-protein interactions (PPIs) are central to many cellular processes, and the assembly of proteins into complexes is essential for biological function. Clustering with overlapping neighborhood expansion (ClusterONE) has been successfully used to detect overlapping protein complexes in both weighted and unweighted PPI networks. Here, we present ClusterONE Web, a freely available, web-based tool that brings the functionality of ClusterONE into an accessible, user-friendly environment. The platform includes a database of preprocessed PPI datasets covering multiple organisms, reducing the need for manual data collection and preprocessing, while also allowing users to upload their own interaction data. Detected complexes are presented through an interactive interface, facilitating their exploration without requiring specialized software installation. The server also provides built-in Gene Ontology enrichment analysis to aid in the functional interpretation of identified complexes. ClusterONE Web is platform-independent and available at https://paccanarolab.org/clusteroneweb/.

Indexed as

Multiprotein ComplexesProtein Interaction MappingSoftwareAnimalsCluster AnalysisDatabases, ProteinGene OntologyHumansInternetProtein Interaction MapsUser-Computer InterfaceMultiprotein Complexes

Identifiers

PMID40377081
PMCPMC12230668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.