Evidence map›Paper›PMID 40377065›Full record

ArticleHistology and histopathology2026

Pachymic acid ameliorates polycystic ovary syndrome via inactivating Akt/ERK signaling.

Dongmei Ji, Chunhua Zhang, Fang Fang, Yuanyuan Yi

Abstract read
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Article in Histology and histopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dongmei JiNanjing University of Chinese Medicine, Jiangsu, China.
Chunhua ZhangDepartment of Gynecology, Huaian Maternal and Child Health Hospital, Huaian, Jiangsu, China.
Fang FangDepartment of Gynecology, Huaian Maternal and Child Health Hospital, Huaian, Jiangsu, China.
Yuanyuan YiNanjing University of Chinese Medicine, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePolycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder that adversely affects women's health and quality of life. Pachymic acid (PA), a bioactive ingredient from

methodsFemale Sprague-Dawley rats were treated with letrozole to induce PCOS. The ovarian granulosa cell line (KGN) was exposed to lipopolysaccharide (LPS) to mimic PCOS

resultsPA attenuated LPS-induced lactate dehydrogenase release (

conclusionPA protects against PCOS and attenuates cell apoptosis by inactivating Akt and ERK signaling.

Indexed as

MAP Kinase Signaling SystemPolycystic Ovary SyndromeProto-Oncogene Proteins c-aktTriterpenesAnimalsApoptosisCell LineDisease Models, AnimalFemaleGranulosa CellsLetrozoleOvaryRatsRats, Sprague-DawleySignal TransductionLetrozolepachymic acidProto-Oncogene Proteins c-aktTriterpenes

Identifiers

PMID40377065

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.