In one paragraphArticle in ChemistryOpen, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
Xuemei LiNational Engineering Research Center of Industrial Enzymes and Tianjin Engineering Research Center of Biocatalytic Technology, National Center of Technology Innovation for Synthetic Biology, and Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.ORCID 0000-0001-8844-2732 Liangyan ZhuNational Engineering Research Center of Industrial Enzymes and Tianjin Engineering Research Center of Biocatalytic Technology, National Center of Technology Innovation for Synthetic Biology, and Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Qiong WuNational Engineering Research Center of Industrial Enzymes and Tianjin Engineering Research Center of Biocatalytic Technology, National Center of Technology Innovation for Synthetic Biology, and Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Rui ZhangNational Engineering Research Center of Industrial Enzymes and Tianjin Engineering Research Center of Biocatalytic Technology, National Center of Technology Innovation for Synthetic Biology, and Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.ORCID 0000-0002-7667-4453 Yiyin LiuNational Engineering Research Center of Industrial Enzymes and Tianjin Engineering Research Center of Biocatalytic Technology, National Center of Technology Innovation for Synthetic Biology, and Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.ORCID 0000-0003-0636-0042 Na LiuNational Engineering Research Center of Industrial Enzymes and Tianjin Engineering Research Center of Biocatalytic Technology, National Center of Technology Innovation for Synthetic Biology, and Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.ORCID 0000-0003-1432-3858 Jinhui FengNational Engineering Research Center of Industrial Enzymes and Tianjin Engineering Research Center of Biocatalytic Technology, National Center of Technology Innovation for Synthetic Biology, and Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.ORCID 0000-0001-9320-7323 Qiaqing WuNational Engineering Research Center of Industrial Enzymes and Tianjin Engineering Research Center of Biocatalytic Technology, National Center of Technology Innovation for Synthetic Biology, and Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.ORCID 0000-0001-7405-1562 Dunming ZhuNational Engineering Research Center of Industrial Enzymes and Tianjin Engineering Research Center of Biocatalytic Technology, National Center of Technology Innovation for Synthetic Biology, and Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.ORCID 0000-0001-8783-5358 Funding
National Key R & D Program of China 2019YFA0905300National Natural Science Foundation of China 32171477Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project TSBICIP-CXRC-052Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project TSBICIP-KJGG-009Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project TSBICIP-PTJJ-007
6 · The paper itselfAbstract
22-Hydroxy-23,24-bisnorchol-4-ene-3-one (4-HBC) and 3-oxo-4,17-pregnadiene-20-carboxylic acid methyl ester (PDCE) are useful precursors for the synthesis of steroidal active pharmaceutical ingredients. In this study, we identify the sterol metabolism-related genes, which encode the aldolases (Ltp2 and Thl) and carboxylic acid reductases (CAR) in Mycolicibacterium neoaurum NRRL B-3805 (B3805), by analysis of the metabolites from phytosterols biotransformation. Based on these results, a genetically modified strain is constructed by disrupting the kstD, ltp2, and hsd4A genes and overexpressing the aldolase gene (thl) in the strain B3805. This recombinant strain (B3805V) is able to transform 5 g L
Indexed as
ActinobacteriaPhytosterolsSteroidsAldehyde-LyasesBiotransformationMycobacteriaceaeAldehyde-LyasesPhytosterolsSteroidsaldolasesbiotransformationscarboxylic acid reductasesMycolicibacterium neoaurumphytosterolssteroidal intermediates
Identifiers
PMID40376916
PMCPMC12409849
What OpenQuestion holds
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