ArticleACS sustainable chemistry & engineering2025
Harnessing the Potential of 5-Hydroxymethylfurfural: Investigating Solubility and Stability in Tailored Deep Eutectic Solvents.
Article in ACS sustainable chemistry & engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Stable and Water-Tolerant Deep Eutectic Solvent from Biomass-Derived 5‑Hydroxymethylfurfural (HMF) and Levulinic Acid.ACS sustainable chemistry & engineering · 2026Article
- Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The potential of 5-hydroxymethylfurfural (HMF) as a platform chemical for sustainable biobased products is widely recognized. However, its practical applications are often constrained by stability challenges. This study examines the solubility and chemical stability of HMF in 15 paradigmatic deep eutectic solvents (DES), formed by combining five hydrogen bond acceptors (HBAs: betaine, choline chloride, choline acetate, L-carnitine, and l-proline) and three hydrogen bond donors (HBDs: glycerol, ethylene glycol, and levulinic acid). Our findings reveal that HMF demonstrates high solubility and remarkable stability across the studied DES. Only a few cases of HMF degradation were observed and discussed, with specific degradation pathways identified in certain solvent mixtures. Notably, the HBAs within the DES play a crucial role in significantly enhancing the stability of HMF, establishing a foundation for its use as a renewable synthon in organic chemistry using environmentally benign solvents. These findings represent a significant step forward in aligning the synthetic design with the principles of green chemistry.
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Registered trials
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