ReviewBiophysical reviews2025
Surfactant protein SP-B: one ring to rule the molecular and biophysical mechanisms of the pulmonary surfactant system.
Review in Biophysical reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Hydrolysis and depletion of phosphatidylglycerol at peak murine acute lung injury.Journal of lipid research · 2026Article
- Biophysical reviews (ISSUE 2 2025): LAFeBS, alive, kicking, and growing: the story continues...Biophysical reviews · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulmonary surfactant is a lipid/protein complex crucial to maintain mammalian lungs open, as it facilitates breathing mechanics through a dramatic reduction of surface tension at the air-liquid interface. Intensive research during a few decades has identified many of the molecular actors defining the molecular and biophysical mechanisms of surfactant at the airspaces. Pulmonary surfactant protein SP-B has been undoubtedly identified as the most important and essential molecule to allow for air breathing in the mammalian lungs, as its absence is incompatible with life. We now know that SP-B directs the assembly of surfactant complexes into the lamellar bodies of type II pneumocytes, their secretion, adsorption, and reorganization at the interface as well as the homeostasis of the surfactant layer during different pathophysiological contexts. This review summarizes current models on SP-B structure and biophysical function, supporting how the activity of SP-B may be crucial for the design and production of a new generation of therapeutic products in respiratory medicine.
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Registered trials
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