ArticleNature. Mental health2024
Neurocircuitry basis of motor cortex-related analgesia as an emerging approach for chronic pain management.
Article in Nature. Mental health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Trial
- Transcranial direct current stimulation over motor cortex improves pain in end stage renal disease a randomized controlled trial.Scientific reports · 2025Trial
- Chronic pain and oscillatory neuroplasticity: Review on impaired compensatory network responses in resting-state electroencephalography.Brain network disorders · 2026Article
- A scoping review of music-based pain treatment mechanism research.Pain reports · 2026Review
- Long-Lasting Changes of Repeated Anodal Transcranial Direct Current Stimulation in Decreasing Chronic Pain in Patients with Multiple Sclerosis: A Case Series.Brain sciences · 2026Article
- Perspectives Among Veterans with Chronic Pain and Co-Occurring Mild Traumatic Brain Injury: Mixed-Method Findings from a Neuromodulation and Yoga Intervention.International journal of environmental research and public health · 2026Article
- Inspiratory Muscle Training for Patients With Chronic Obstructive Pulmonary Disease: A Narrative Review.Cureus · 2026Review
- Identifying neural oscillation and phase synchronization abnormalities in migraine and their predictive values in transcranial magnetic stimulation.Journal of oral & facial pain and headache · 2026Article
- Temporal Interference Stimulation of the Motor Cortex Produces Frequency-Dependent Analgesia.bioRxiv : the preprint server for biology · 2026Article
- Neuroimaging-Guided Insights into the Molecular and Network Mechanisms of Chronic Pain and Neuromodulation.International journal of molecular sciences · 2026Review
- Therapeutic effect of mirror visual feedback therapy on neuropathic pain in patients with total brachial plexus injuries.Frontiers in neurology · 2026Article
- Conditioned pain modulation, cortical imbalance, and arthrogenic muscle inhibition: an integrative model with implications for exercise in chronic pain.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- A randomised, double-blind, sham-controlled, 2×2 factorial trial of aerobic vs. non-aerobic exercise and motor cortex transcranial direct current stimulation in fibromyalgia: effects on clinical outcomes and descending pain modulation.Lancet regional health. Americas · 2026Article
- Cortical Control of Itch Sensation by Vasoactive Intestinal Polypeptide-Expressing Interneurons in the Anterior Cingulate Cortex.Neuroscience bulletin · 2025Article
- The Impact of Epidural Analgesia on the Dynamics of Labor and Perinatal Outcomes in Nulliparous Women: A Prospective Cohort Study.Medicina (Kaunas, Lithuania) · 2025Article
- Transcranial Direct Current Stimulation (tDCS) in Diabetes: A Focused and Mechanistic Review of Symptom and Function Outcomes.Journal of clinical medicine · 2025Review
- Compensatory Failure of Autonomic Regulation in Phantom Limb Pain and Its Correlation with Maladaptive Plasticity: A Cross-Sectional HRV Study in Amputees.Biomedicines · 2025Article
- Preemptive transcranial direct current stimulation mitigates susceptibility to persistent pain.Communications biology · 2025Article
- Identifying neural circuitry abnormalities in neuropathic pain with transcranial magnetic stimulation and electroencephalogram co-registration.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- The Impact of Obesity as a Peripheral Disruptor of Brain Inhibitory Mechanisms in Fibromyalgia: A Cross-Sectional Study.Journal of clinical medicine · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Aside from movement initiation and control, the primary motor cortex (M1) has been implicated in pain modulation mechanisms. A large body of clinical data has demonstrated that stimulation and behavioral activation of M1 result in clinically important pain relief in patients with specific chronic pain syndromes. However, despite its clinical importance, the full range of circuits for motor cortex-related analgesia (MCRA) remains an enigma. This review draws on insights from experimental and clinical data and provides an overview of the neurobiological mechanisms of MCRA, with particular emphasis on its neurocircuitry basis. Based on structural and functional connections of the M1 within the pain connectome, neural circuits for MCRA are discussed at different levels of the neuroaxis, specifically, the endogenous pain modulation system, the thalamus, the extrapyramidal system, non-noxious somatosensory systems, and cortico-limbic pain signatures. We believe that novel insights from this review will expedite our understanding of M1-induced pain modulation and offer hope for successful mechanism-based refinements of this interventional approach in chronic pain management.
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