Evidence map›Paper›PMID 40376383›Full record

ArticleCureus2025

Pharmacokinetics of Dexmedetomidine in an In Vitro Circuit Model and In Vivo Extracorporeal Membrane Oxygenation Rat Model.

Yuhki Sato, Erina Mothoishi, Rina Kakuba, Yuka Nagatsuka, Takuya Abe, Yutaka Fujii

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yuhki SatoDepartment of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, JPN.
Erina MothoishiDepartment of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, JPN.
Rina KakubaDepartment of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, JPN.
Yuka NagatsukaDepartment of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, JPN.
Takuya AbeDepartment of Clinical Engineering and Medical Technology, Niigata University of Health and Welfare, Niigata, JPN.
Yutaka FujiiDepartment of Clinical Engineering and Medical Technology, Niigata University of Health and Welfare, Niigata, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesExtracorporeal membrane oxygenation (ECMO) causes variability in the pharmacokinetics (PK) of drugs. Fluctuations in the PK profile of dexmedetomidine (DEX) might significantly reduce the likelihood of obtaining a therapeutic effect. The study aimed to clarify the effect of ECMO on the PK of DEX.

methods

resultsIn the

conclusionThese results suggest that ECMO may affect the efficacy or increase the risk of side effects associated with DEX

Indexed as

dexmedetomidineextracorporeal membrane oxygenationnoncompartmental analysisnonlinear mixed-effects modelingpharmacokinetics

Identifiers

PMID40376383
PMCPMC12079145

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.