ArticleHealth science reports2025
A Causal Association Study Between Chronic Kidney Disease and Oral Health: A Mendelian Randomization Study.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Previous studies have shown that chronic kidney disease (CKD) can lead to changes in oral health, but the conclusions remain controversial. Thus, we conducted a Mendelian randomization (MR) study from the perspective of genetic analysis to assess the causal association between CKD and oral health conditions, including dental caries, pulp diseases, periapical tissues, and diseases of the gum and periodontal tissues. Methods: We performed inverse variance weighted (IVW) random effects MR analyses and several sensitivity MR analyses using summary statistics from genome-wide association studies (GWAS). The data were derived from the European population in 2021, which included 3902 cases of CKD, 4170 cases of dental caries, 5354 cases of diseases of the pulp and periapical tissues, and 4120 cases of gingivitis and periodontal diseases. Results: We found a positive causal relationship between CKD and dental caries, and the effect odds ratio (OR) of CKD on dental caries was 1.368 (95% CI, 1.124-1.664; Conclusions: Our findings suggest that CKD could affect oral health and only with a direct causal link to dental caries. However, pulp diseases, periapical tissues, and diseases of the gum and periodontal tissues have no direct causal relationship.
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