ArticleFrontiers in public health2025
Prenatal exposure to barium and arsenic and the odds of congenital heart defects in offspring: a nested case-control study within a birth cohort in Lanzhou, China.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Associations of exposure to cotinine, polycyclic aromatic hydrocarbon, and metal(loid) mixtures during pregnancy with birth weight: the MIEHR study.Journal of exposure science & environmental epidemiology · 2026Article
- Arsenic Exposure During Pregnancy: Impacts to Maternal and Offspring Cardiovascular Health.Medical research archives · 2026Article
- The Impact of Arsenic, Cadmium, Lead, Mercury, and Thallium Exposure on the Cardiovascular System and Oxidative Mechanisms in Children.Current issues in molecular biology · 2025Review
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Authors and funding
12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Previous studies have identified that exposure to heavy metals increases the prevalence of congenital heart defects (CHDs); however, limited information exists regarding the association between combined exposure to barium (Ba) and arsenic (As), and CHDs. This study aims to investigate the association between prenatal exposure to Ba and As (both independently and in combination) and the risk of CHDs in offspring. Methods: In a birth cohort study conducted in Lanzhou, China, a total of 97 mother-newborn pairs were designated as the case group, with an additional 194 pairs constituting the control group. The concentrations of Ba and As in maternal blood were quantified utilizing an inductively coupled plasma mass spectrometer. A multivariate logistic regression model was employed to examine the association between Ba and As exposure levels and the risk of neonatal CHDs and their subtypes. Interaction effects were further evaluated through the application of both additive and multiplicative models. Results: The concentration of As in the blood of pregnant women is positively correlated with Ba levels. Higher concentrations of maternal blood Ba level was associated with greater odds of CHDs ( Conclusion: Exposure to Ba or As individually, as well as combined exposure to both, is significantly associated with an increased risk of CHDs in offspring.
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