Evidence map›Paper›PMID 40375922›Full record

ArticleResearch (Washington, D.C.)2025

Functional Ultrasound Imaging of Auditory Responses in Comatose Patients.

Zihao Chen, Na Li, Caihua Xi, Jiaru He, Jiejun Zhu, Gang Wu, Jinzhao Xia, Chunlong Fei, Lei Sun, Hongzhi Xu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zihao ChenGuangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong 519031, P. R. China.ORCID https://orcid.org/0009-0005-0766-6715
Na LiGuangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong 519031, P. R. China.
Caihua XiDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University; National Center for Neurological Disorders; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration; Neurosurgical Institute of Fudan University; Shanghai Clinical Medical Center of Neurosurgery; Department of Neurosurgery & Neurocritical Care, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, P. R. China.
Jiaru HeGuangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong 519031, P. R. China.
Jiejun ZhuGuangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong 519031, P. R. China.
Gang WuDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University; National Center for Neurological Disorders; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration; Neurosurgical Institute of Fudan University; Shanghai Clinical Medical Center of Neurosurgery; Department of Neurosurgery & Neurocritical Care, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, P. R. China.
Jinzhao XiaGuangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong 519031, P. R. China.
Chunlong FeiSchool of Microelectronics, Xidian University, Xi'an, Shannxi, P. R. China.
Lei SunDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR 999077, P. R. China.
Hongzhi XuDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University; National Center for Neurological Disorders; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration; Neurosurgical Institute of Fudan University; Shanghai Clinical Medical Center of Neurosurgery; Department of Neurosurgery & Neurocritical Care, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, P. R. China.
Zhihai QiuGuangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong 519031, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bedside monitoring of brain function in severely brain-injured patients remains a critical clinical challenge. We demonstrate the translational potential of functional ultrasound (fUS) imaging for this purpose. In 6 comatose patients (Glasgow coma scale ≤ 8) with cranial windows after decompressive craniectomy, we used a 7.8-MHz transducer optimized for cortical depths of 1.5 to 4 cm to perform real-time fUS during auditory stimulation. We observed task-related increases in regional cerebral blood flow (rCBF) in relevant brain regions (

Identifiers

PMID40375922
PMCPMC12079190

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.