Evidence map›Paper›PMID 40375879›Full record

ArticleGlobal advances in integrative medicine and health

The Feasibility of Investigating Acupuncture in Patients With COVID-19 Related Olfactory Dysfunction.

Michael F Armstrong, Thomas J O'Byrne, Jason J Calva, Molly J Mallory, Sara E Bublitz, Alexander Do, Carlos D Pinheiro Neto, Garret W Choby, Erin K O'Brien, Brent A Bauer and 1 more

Abstract read
In one paragraph

Article in Global advances in integrative medicine and health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Michael F ArmstrongDepartment of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, MN, USA.ORCID https://orcid.org/0000-0002-6786-3850
Thomas J O'ByrneDivision of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
Jason J CalvaDepartment of General Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Molly J MalloryDepartment of General Internal Medicine, Mayo Clinic, Rochester, MN, USA.ORCID https://orcid.org/0000-0002-3646-4179
Sara E BublitzDepartment of General Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Alexander DoDepartment of General Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Carlos D Pinheiro NetoDepartment of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, MN, USA.
Garret W ChobyDepartment of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, MN, USA.
Erin K O'BrienDepartment of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, MN, USA.
Brent A BauerDepartment of General Internal Medicine, Mayo Clinic, Rochester, MN, USA.ORCID https://orcid.org/0000-0003-3453-6906
Janalee K StokkenDepartment of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, MN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Olfactory dysfunction (OD) is a common symptom in patients with coronavirus disease 2019 (COVID-19) with limited treatment options. Objective: This pilot study aimed to investigate an acupuncture protocol in patients with COVID-19 related OD. Methods: Thirty patients were randomized into 2 groups. The standard group was treated with budesonide nasal irrigation and olfactory training. The acupuncture group received ten sessions of acupuncture therapy in addition to the standard group treatment. Olfaction was assessed using the University of Pennsylvania Smell Identification Test, 10-point visual analog scale, and Sino-Nasal Outcome Test at baseline and after 3 months of treatment. Differences between study arms were compared using Fisher's exact and Wilcoxon rank sum tests. Results: Eighteen of the 30 (60%) enrolled patients completed the study, including 11 (73%) in the standard and 7 (47%) in the acupuncture group. Reasons for participant drop-out included cost of travel and time constraints. There were no acupuncture complications. Conclusions: Acupuncture as an adjunct therapy for COVID-19 related OD is well tolerated. Subsequent studies with larger sample sizes are needed to assess the effect of acupuncture on OD.

Indexed as

acupunctureCOVID-19olfactionolfactory dysfunctionUniversity of Pennsylvania smell identification test

Identifiers

PMID40375879
PMCPMC12078969

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.