ReviewJournal of clinical and experimental dentistry2025
Comparative Evaluation of Autologous Platelet Aggregates Versus Blood Clot On The Outcome Of Regenerative Endodontic Therapy: A Systematic Review and Meta-Analysis.
Review in Journal of clinical and experimental dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Favorable Eruption Despite External Replacement Root Resorption in Delayed Replantation of Avulsed Teeth Treated With Regenerative Endodontics-An Observational Study.Dental traumatology : official publication of International Association for Dental Traumatology · 2026Observational
- Regenerative endodontics: current concepts, clinical challenges, and emerging therapies.Brazilian oral research · 2026Review
- Evaluation of platelet concentrates in regenerative endodontics: a systematic review and meta-analysis.Restorative dentistry & endodontics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Regenerative endodontics represents a transformative approach to dental care, revitalizing necrotic teeth. This systematic review and meta-analysis evaluated the role of autologous platelet aggregates compared to the traditional blood clot method in regenerative endodontics. Material and Methods: A systematic search was conducted in PubMed, Scopus, EBSCO, Open Grey, and Google Scholar between 1st-12th August 2024. Case series, RCTs, retrospective studies, and case reports were included. Meta-analysis on RCTs and case series utilized RevMan 5.4 software, with Results: Nineteen studies met inclusion criteria, of which 13 were evaluated for risk of bias-11 showed low risk, and 2 were moderate. Rates of complete apical closure using PRF, BC, PRP, and CGF scaffolds ranged from 61.76% to 100%. Statistical analysis revealed no significant differences between autologous platelet aggregates and BC for outcomes such as complete apical closure (BC vs. PRP: Conclusions: BC remains an effective primary scaffold for non-vital teeth with open apexes. PRP and PRF are viable alternatives when intracanal blood induction is challenging. Overall, platelet aggregates and BC showed comparable clinical and radiographic outcomes.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.