Evidence map›Paper›PMID 40375826›Full record

ArticleEuropean journal of immunology2025

Surface CD69-Negative CD4 and CD8 Bone Marrow-Resident Human Memory T Cells.

Emilia Schneider Revueltas, Marta Ferreira-Gomes, Gabriela Maria Guerra, Pawel Durek, Frederik Heinrich, Anna Casanovas Subirana, Koji Tokoyoda, Jun Dong, Simon Reinke, Sebastian Hardt and 7 more

Abstract read
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Emilia Schneider RevueltasDeutsches Rheuma-Forschungszentrum Berlin, ein Institut der Leibniz Gemeinschaft, Berlin, Germany.ORCID 0000-0003-1402-6263
Marta Ferreira-GomesDeutsches Rheuma-Forschungszentrum Berlin, ein Institut der Leibniz Gemeinschaft, Berlin, Germany.
Gabriela Maria GuerraDeutsches Rheuma-Forschungszentrum Berlin, ein Institut der Leibniz Gemeinschaft, Berlin, Germany.
Pawel DurekDeutsches Rheuma-Forschungszentrum Berlin, ein Institut der Leibniz Gemeinschaft, Berlin, Germany.
Frederik HeinrichDeutsches Rheuma-Forschungszentrum Berlin, ein Institut der Leibniz Gemeinschaft, Berlin, Germany.
Anna Casanovas SubiranaDeutsches Rheuma-Forschungszentrum Berlin, ein Institut der Leibniz Gemeinschaft, Berlin, Germany.
Koji TokoyodaDeutsches Rheuma-Forschungszentrum Berlin, ein Institut der Leibniz Gemeinschaft, Berlin, Germany.
Jun DongDeutsches Rheuma-Forschungszentrum Berlin, ein Institut der Leibniz Gemeinschaft, Berlin, Germany.ORCID 0000-0001-5218-7979
Simon ReinkeBerlin Institute of Health, Charité-Universitätsmedizin Berlin and BIH Center for Regenerative Therapies (BCRT), Berlin, Germany.
Sebastian HardtDepartment of Orthopedic Surgery, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Christian HipflDepartment of Orthopedic Surgery, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Thomas DörnerDeutsches Rheuma-Forschungszentrum Berlin, ein Institut der Leibniz Gemeinschaft, Berlin, Germany.
Carsten PerkaDepartment of Orthopedic Surgery, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Ute HoffmannDeutsches Rheuma-Forschungszentrum Berlin, ein Institut der Leibniz Gemeinschaft, Berlin, Germany.
Hyun-Dong ChangDeutsches Rheuma-Forschungszentrum Berlin, ein Institut der Leibniz Gemeinschaft, Berlin, Germany.ORCID 0000-0002-7341-4533
Mir-Farzin MashreghiDeutsches Rheuma-Forschungszentrum Berlin, ein Institut der Leibniz Gemeinschaft, Berlin, Germany.ORCID 0000-0002-8015-6907
Andreas RadbruchDeutsches Rheuma-Forschungszentrum Berlin, ein Institut der Leibniz Gemeinschaft, Berlin, Germany.ORCID 0000-0001-5753-0000

Funding

Bundesministerium für Bildung und Forschung CONANBundesministerium für Bildung und Forschung TReATChinesisch-Deutsche Zentrum für Wissenschaftsförderung C-0072Deutsche Forschungsgemeinschaft 389687267Deutsche Forschungsgemeinschaft Collaborative Research Centre1444Dr. Rolf M. Schwiete FoundationEuropean Regional Development Fund EFRE 1.8/11European Regional Development Fund ERDF 2014-2020Leibniz-Gemeinschaft ImpACTLeibniz-Gemeinschaft Leibniz Collaborative Program K470/2022Leibniz-Gemeinschaft TargArtSecihti Secretaria de Ciencia, Humanidades, Tecnología e Innovación. Gobierno de México CONACYT-DAAD 2021
6 · The paper itself

Abstract

Across tissues, tissue-resident memory T cells have been defined as cells that express CD69 on their cell surface but not sphingosine-1-phosphate receptor 1 (S1PR1), the receptor for the tissue-egress signal sphingosine-1-phosphate (S1P). It is less clear whether CD69-negative memory T cells are also tissue-resident. Here, we compare transcriptomes and T cell receptor repertoires of individual CD4 and CD8 memory T cells from paired blood and bone marrow samples from three human donors. CD69

Indexed as

Antigens, CDAntigens, Differentiation, T-LymphocyteBone MarrowBone Marrow CellsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesImmunologic MemoryLectins, C-TypeMemory T CellsCD69 AntigensHumansLymphocyte ActivationLysophospholipidsSphingosineSphingosine-1-Phosphate ReceptorsAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensLectins, C-TypeLysophospholipidsS1PR1 protein, humanSphingosinesphingosine 1-phosphateSphingosine-1-Phosphate Receptorsbone marrowCD69memory T lymphocytesT cell receptor repertoiretranscriptome

Identifiers

PMID40375826
PMCPMC12082384

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.