ArticleChemMedChem2025
Impact of Chelation on Reactivity and Cytotoxicity of Hemilabile Biphenyl Gold(III) N-Heterocyclic Carbene Complexes.
Article in ChemMedChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Mechanochemistry Meets Catalysis: Metal Complexes for Greener Organic Transformations.Angewandte Chemie (International ed. in English) · 2026Review
- Impact of Chelation on Reactivity and Cytotoxicity of Hemilabile Biphenyl Gold(III) N-Heterocyclic Carbene Complexes.ChemMedChem · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
Although great progresses have been accomplished in the field of antineoplastic treatments, the need for chemotherapy agents with new mechanisms of action remains essential. Metal complexes presenting hemilabile ligands could combine structural toxicity upon full coordination of the ligand and reactive toxicity upon ligand partial decoordination and direct coordination of the metal center to biological targets. To investigate the relevance of hemilability in the case of Au(III) complexes, we synthesized eight open biphenyl gold(III) N-heterocyclic carbene complexes coined BGC of general formula [(C^C)Au(NHC^het)Cl] where het is a pyridine-type entity and C^C is 4,4'-diterbutylbiphenyl. Chloride abstraction afforded the chelated cationic complexes [(C^C)Au(NHC^N)]PF
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Registered trials
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