Evidence map›Paper›PMID 40375822›Full record

ArticleEuropean journal of immunology2025

The Human Bone Marrow May Offer an IL-15-Dependent Survival Niche for EOMES

Nadia Pulvirenti, Chiara Vasco, Camilla Righetti, Petra Dadova, Giacomo Boffa, Alice Laroni, Tiziana Vigo, Anna Maria Raiola, Maria Cristina Crosti, Stefano Maglie and 5 more

Abstract read
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Nadia PulvirentiFondazione Istituto Nazionale di Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.
Chiara VascoFondazione Istituto Nazionale di Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.
Camilla RighettiFondazione Istituto Nazionale di Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.
Petra DadovaFondazione Istituto Nazionale di Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.
Giacomo BoffaDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy.ORCID 0000-0003-2220-9422
Alice LaroniDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy.
Tiziana VigoIRCCS Ospedale Policlinico San Martino, Genova, Italy.
Anna Maria RaiolaEmatologia e Terapie Cellulari, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
Maria Cristina CrostiFondazione Istituto Nazionale di Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.
Stefano MaglieFondazione Istituto Nazionale di Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.
Luca ValentiDepartment of Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale, Maggiore Policlinico, Milan, Italy.
Daniele PratiDepartment of Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale, Maggiore Policlinico, Milan, Italy.
Sergio AbriganiFondazione Istituto Nazionale di Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.
Antonio UccelliDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy.
Jens GeginatFondazione Istituto Nazionale di Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.ORCID 0000-0003-4813-0384

Funding

Fondazione Italiana Sclerosi Multipla 2023/R-Multi/024
6 · The paper itself

Abstract

Maintenance of memory T-cells in the bone marrow and systemically depends on the homeostatic cytokines IL-7 and IL-15. An immunological memory may also exist for regulatory T-cells. EOMES

Indexed as

Bone MarrowBone Marrow CellsInterleukin-15T-Box Domain ProteinsT-Lymphocytes, RegulatoryCD8-Positive T-LymphocytesCell SurvivalFemaleHumansImmunologic MemoryInterleukin-7Interleukin-7 Receptor alpha SubunitMaleMultiple SclerosisReceptors, Interleukin-7EOMES protein, humanIL15 protein, humanIL7R protein, humanInterleukin-15Interleukin-7Interleukin-7 Receptor alpha SubunitReceptors, Interleukin-7T-Box Domain Proteinsbone marrowCD69memory T lymphocytesregulatory T‐cells

Identifiers

PMID40375822
PMCPMC12082382

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.